Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Targeting self-renewing cancer cells without deleterious side effects in normal tissues has proven challenging. Here, the authors show that the well-tolerated HDAC inhibitor Quisinostat safely inhibits tumor maintenance and disease relapse by restoring high levels of histone H1.0.

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Auteurs principaux: Cristina Morales Torres, Mary Y. Wu, Sebastijan Hobor, Elanor N. Wainwright, Matthew J. Martin, Harshil Patel, William Grey, Eva Grönroos, Steven Howell, Joana Carvalho, Ambrosius P. Snijders, Michael Bustin, Dominique Bonnet, Paul D. Smith, Charles Swanton, Michael Howell, Paola Scaffidi
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
Q
Accès en ligne:https://doaj.org/article/f8d840aac93c41c6937b76b29e6d3cbc
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Résumé:Targeting self-renewing cancer cells without deleterious side effects in normal tissues has proven challenging. Here, the authors show that the well-tolerated HDAC inhibitor Quisinostat safely inhibits tumor maintenance and disease relapse by restoring high levels of histone H1.0.

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