Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Targeting self-renewing cancer cells without deleterious side effects in normal tissues has proven challenging. Here, the authors show that the well-tolerated HDAC inhibitor Quisinostat safely inhibits tumor maintenance and disease relapse by restoring high levels of histone H1.0.

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Autores principales:	Cristina Morales Torres, Mary Y. Wu, Sebastijan Hobor, Elanor N. Wainwright, Matthew J. Martin, Harshil Patel, William Grey, Eva Grönroos, Steven Howell, Joana Carvalho, Ambrosius P. Snijders, Michael Bustin, Dominique Bonnet, Paul D. Smith, Charles Swanton, Michael Howell, Paola Scaffidi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8d840aac93c41c6937b76b29e6d3cbc
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spelling	oai:doaj.org-article:f8d840aac93c41c6937b76b29e6d3cbc2021-12-02T14:41:23ZSelective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis10.1038/s41467-020-15615-z2041-1723https://doaj.org/article/f8d840aac93c41c6937b76b29e6d3cbc2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15615-zhttps://doaj.org/toc/2041-1723Targeting self-renewing cancer cells without deleterious side effects in normal tissues has proven challenging. Here, the authors show that the well-tolerated HDAC inhibitor Quisinostat safely inhibits tumor maintenance and disease relapse by restoring high levels of histone H1.0.Cristina Morales TorresMary Y. WuSebastijan HoborElanor N. WainwrightMatthew J. MartinHarshil PatelWilliam GreyEva GrönroosSteven HowellJoana CarvalhoAmbrosius P. SnijdersMichael BustinDominique BonnetPaul D. SmithCharles SwantonMichael HowellPaola ScaffidiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristina Morales Torres Mary Y. Wu Sebastijan Hobor Elanor N. Wainwright Matthew J. Martin Harshil Patel William Grey Eva Grönroos Steven Howell Joana Carvalho Ambrosius P. Snijders Michael Bustin Dominique Bonnet Paul D. Smith Charles Swanton Michael Howell Paola Scaffidi Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
description	Targeting self-renewing cancer cells without deleterious side effects in normal tissues has proven challenging. Here, the authors show that the well-tolerated HDAC inhibitor Quisinostat safely inhibits tumor maintenance and disease relapse by restoring high levels of histone H1.0.
format	article
author	Cristina Morales Torres Mary Y. Wu Sebastijan Hobor Elanor N. Wainwright Matthew J. Martin Harshil Patel William Grey Eva Grönroos Steven Howell Joana Carvalho Ambrosius P. Snijders Michael Bustin Dominique Bonnet Paul D. Smith Charles Swanton Michael Howell Paola Scaffidi
author_facet	Cristina Morales Torres Mary Y. Wu Sebastijan Hobor Elanor N. Wainwright Matthew J. Martin Harshil Patel William Grey Eva Grönroos Steven Howell Joana Carvalho Ambrosius P. Snijders Michael Bustin Dominique Bonnet Paul D. Smith Charles Swanton Michael Howell Paola Scaffidi
author_sort	Cristina Morales Torres
title	Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
title_short	Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
title_full	Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
title_fullStr	Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
title_full_unstemmed	Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
title_sort	selective inhibition of cancer cell self-renewal through a quisinostat-histone h1.0 axis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f8d840aac93c41c6937b76b29e6d3cbc
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Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

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