Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model o...

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Autores principales:	Yi Han, Qiong Jia, Pedram Shafiei Jahani, Benjamin P. Hurrell, Calvin Pan, Pin Huang, Janet Gukasyan, Nicholas C. Woodward, Eleazar Eskin, Frank D. Gilliland, Omid Akbari, Jaana A. Hartiala, Hooman Allayee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8d9585256e74637bddfa208274a4cd5
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spelling	oai:doaj.org-article:f8d9585256e74637bddfa208274a4cd52021-12-02T14:42:33ZGenome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma10.1038/s41467-020-15649-32041-1723https://doaj.org/article/f8d9585256e74637bddfa208274a4cd52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15649-3https://doaj.org/toc/2041-1723Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model of airway hyperreactivity.Yi HanQiong JiaPedram Shafiei JahaniBenjamin P. HurrellCalvin PanPin HuangJanet GukasyanNicholas C. WoodwardEleazar EskinFrank D. GillilandOmid AkbariJaana A. HartialaHooman AllayeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Han Qiong Jia Pedram Shafiei Jahani Benjamin P. Hurrell Calvin Pan Pin Huang Janet Gukasyan Nicholas C. Woodward Eleazar Eskin Frank D. Gilliland Omid Akbari Jaana A. Hartiala Hooman Allayee Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
description	Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model of airway hyperreactivity.
format	article
author	Yi Han Qiong Jia Pedram Shafiei Jahani Benjamin P. Hurrell Calvin Pan Pin Huang Janet Gukasyan Nicholas C. Woodward Eleazar Eskin Frank D. Gilliland Omid Akbari Jaana A. Hartiala Hooman Allayee
author_facet	Yi Han Qiong Jia Pedram Shafiei Jahani Benjamin P. Hurrell Calvin Pan Pin Huang Janet Gukasyan Nicholas C. Woodward Eleazar Eskin Frank D. Gilliland Omid Akbari Jaana A. Hartiala Hooman Allayee
author_sort	Yi Han
title	Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_short	Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_full	Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_fullStr	Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_full_unstemmed	Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_sort	genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f8d9585256e74637bddfa208274a4cd5
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Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

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