Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model o...
Guardado en:
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/f8d9585256e74637bddfa208274a4cd5 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:f8d9585256e74637bddfa208274a4cd5 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:f8d9585256e74637bddfa208274a4cd52021-12-02T14:42:33ZGenome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma10.1038/s41467-020-15649-32041-1723https://doaj.org/article/f8d9585256e74637bddfa208274a4cd52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15649-3https://doaj.org/toc/2041-1723Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model of airway hyperreactivity.Yi HanQiong JiaPedram Shafiei JahaniBenjamin P. HurrellCalvin PanPin HuangJanet GukasyanNicholas C. WoodwardEleazar EskinFrank D. GillilandOmid AkbariJaana A. HartialaHooman AllayeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Yi Han Qiong Jia Pedram Shafiei Jahani Benjamin P. Hurrell Calvin Pan Pin Huang Janet Gukasyan Nicholas C. Woodward Eleazar Eskin Frank D. Gilliland Omid Akbari Jaana A. Hartiala Hooman Allayee Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma |
description |
Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model of airway hyperreactivity. |
format |
article |
author |
Yi Han Qiong Jia Pedram Shafiei Jahani Benjamin P. Hurrell Calvin Pan Pin Huang Janet Gukasyan Nicholas C. Woodward Eleazar Eskin Frank D. Gilliland Omid Akbari Jaana A. Hartiala Hooman Allayee |
author_facet |
Yi Han Qiong Jia Pedram Shafiei Jahani Benjamin P. Hurrell Calvin Pan Pin Huang Janet Gukasyan Nicholas C. Woodward Eleazar Eskin Frank D. Gilliland Omid Akbari Jaana A. Hartiala Hooman Allayee |
author_sort |
Yi Han |
title |
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma |
title_short |
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma |
title_full |
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma |
title_fullStr |
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma |
title_full_unstemmed |
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma |
title_sort |
genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/f8d9585256e74637bddfa208274a4cd5 |
work_keys_str_mv |
AT yihan genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT qiongjia genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT pedramshafieijahani genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT benjaminphurrell genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT calvinpan genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT pinhuang genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT janetgukasyan genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT nicholascwoodward genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT eleazareskin genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT frankdgilliland genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT omidakbari genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT jaanaahartiala genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma AT hoomanallayee genomewideanalysishighlightscontributionofimmunesystempathwaystothegeneticarchitectureofasthma |
_version_ |
1718389667816013824 |