Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model o...

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Autores principales: Yi Han, Qiong Jia, Pedram Shafiei Jahani, Benjamin P. Hurrell, Calvin Pan, Pin Huang, Janet Gukasyan, Nicholas C. Woodward, Eleazar Eskin, Frank D. Gilliland, Omid Akbari, Jaana A. Hartiala, Hooman Allayee
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f8d9585256e74637bddfa208274a4cd5
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spelling oai:doaj.org-article:f8d9585256e74637bddfa208274a4cd52021-12-02T14:42:33ZGenome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma10.1038/s41467-020-15649-32041-1723https://doaj.org/article/f8d9585256e74637bddfa208274a4cd52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15649-3https://doaj.org/toc/2041-1723Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model of airway hyperreactivity.Yi HanQiong JiaPedram Shafiei JahaniBenjamin P. HurrellCalvin PanPin HuangJanet GukasyanNicholas C. WoodwardEleazar EskinFrank D. GillilandOmid AkbariJaana A. HartialaHooman AllayeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yi Han
Qiong Jia
Pedram Shafiei Jahani
Benjamin P. Hurrell
Calvin Pan
Pin Huang
Janet Gukasyan
Nicholas C. Woodward
Eleazar Eskin
Frank D. Gilliland
Omid Akbari
Jaana A. Hartiala
Hooman Allayee
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
description Asthma is a common disease of the airways for which numerous genetic loci have been identified. Here, Han et al. carry out a genome-wide analysis for asthma to identify additional loci, report sex-stratified and genetic risk score analyses, and functionally follow-up one locus using a murine model of airway hyperreactivity.
format article
author Yi Han
Qiong Jia
Pedram Shafiei Jahani
Benjamin P. Hurrell
Calvin Pan
Pin Huang
Janet Gukasyan
Nicholas C. Woodward
Eleazar Eskin
Frank D. Gilliland
Omid Akbari
Jaana A. Hartiala
Hooman Allayee
author_facet Yi Han
Qiong Jia
Pedram Shafiei Jahani
Benjamin P. Hurrell
Calvin Pan
Pin Huang
Janet Gukasyan
Nicholas C. Woodward
Eleazar Eskin
Frank D. Gilliland
Omid Akbari
Jaana A. Hartiala
Hooman Allayee
author_sort Yi Han
title Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_short Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_full Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_fullStr Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_full_unstemmed Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
title_sort genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f8d9585256e74637bddfa208274a4cd5
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