MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation

G protein-coupled receptors APLNR and CXCR4 are crucial for vascular development. Here, the authors show that these two signaling pathways communicate and that in response to blood flow APLNR signaling induces a decrease in CXCR4 expression via miR-139-5p, thereby restricting CXCR4 expression to the...

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Autores principales:	Irinna Papangeli, Jongmin Kim, Inna Maier, Saejeong Park, Aram Lee, Yujung Kang, Keiichiro Tanaka, Omar F. Khan, Hyekyung Ju, Yoko Kojima, Kristy Red-Horse, Daniel G. Anderson, Arndt F. Siekmann, Hyung J. Chun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8d99b3209af438b97ff65e526d3b632
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spelling	oai:doaj.org-article:f8d99b3209af438b97ff65e526d3b6322021-12-02T14:39:15ZMicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation10.1038/ncomms112682041-1723https://doaj.org/article/f8d99b3209af438b97ff65e526d3b6322016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11268https://doaj.org/toc/2041-1723G protein-coupled receptors APLNR and CXCR4 are crucial for vascular development. Here, the authors show that these two signaling pathways communicate and that in response to blood flow APLNR signaling induces a decrease in CXCR4 expression via miR-139-5p, thereby restricting CXCR4 expression to the non-flow exposed tip cells in the retinal vasculature.Irinna PapangeliJongmin KimInna MaierSaejeong ParkAram LeeYujung KangKeiichiro TanakaOmar F. KhanHyekyung JuYoko KojimaKristy Red-HorseDaniel G. AndersonArndt F. SiekmannHyung J. ChunNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irinna Papangeli Jongmin Kim Inna Maier Saejeong Park Aram Lee Yujung Kang Keiichiro Tanaka Omar F. Khan Hyekyung Ju Yoko Kojima Kristy Red-Horse Daniel G. Anderson Arndt F. Siekmann Hyung J. Chun MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
description	G protein-coupled receptors APLNR and CXCR4 are crucial for vascular development. Here, the authors show that these two signaling pathways communicate and that in response to blood flow APLNR signaling induces a decrease in CXCR4 expression via miR-139-5p, thereby restricting CXCR4 expression to the non-flow exposed tip cells in the retinal vasculature.
format	article
author	Irinna Papangeli Jongmin Kim Inna Maier Saejeong Park Aram Lee Yujung Kang Keiichiro Tanaka Omar F. Khan Hyekyung Ju Yoko Kojima Kristy Red-Horse Daniel G. Anderson Arndt F. Siekmann Hyung J. Chun
author_facet	Irinna Papangeli Jongmin Kim Inna Maier Saejeong Park Aram Lee Yujung Kang Keiichiro Tanaka Omar F. Khan Hyekyung Ju Yoko Kojima Kristy Red-Horse Daniel G. Anderson Arndt F. Siekmann Hyung J. Chun
author_sort	Irinna Papangeli
title	MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
title_short	MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
title_full	MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
title_fullStr	MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
title_full_unstemmed	MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
title_sort	microrna 139-5p coordinates aplnr-cxcr4 crosstalk during vascular maturation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f8d99b3209af438b97ff65e526d3b632
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_version_	1718390690523643904

MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation

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