Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy

Abstract The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE with and without therapeutic hypotherm...

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Autores principales:	Kim V. Annink, Linda S. de Vries, Floris Groenendaal, Rian M. J. C. Eijsermans, Manouk Mocking, Monique M. J. van Schooneveld, Jeroen Dudink, Henrica L. M. van Straaten, Manon J. N. L. Benders, Maarten Lequin, Niek E. van der Aa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8daa1133c2b46cb8a2bc14dabf7dc00
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spelling	oai:doaj.org-article:f8daa1133c2b46cb8a2bc14dabf7dc002021-12-02T13:30:51ZMammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy10.1038/s41598-021-83982-82045-2322https://doaj.org/article/f8daa1133c2b46cb8a2bc14dabf7dc002021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83982-8https://doaj.org/toc/2045-2322Abstract The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE with and without therapeutic hypothermia. Additional aims were to assess the associations between MB atrophy, brain volumes (including the hippocampi), white matter microstructure and neurodevelopmental outcome at school-age. Ten-year-old children with HIE were included, who were treated with therapeutic hypothermia (n = 22) or would have qualified but were born before this became standard of care (n = 28). Children completed a neuropsychological and motor assessment and MRI. Mammillary bodies were scored as normal or atrophic at 10 years. Brain volumes were segmented on childhood MRI and DTI scans were analysed using tract-based spatial statistics. Children with HIE suffered from neurocognitive and memory problems at school-age, irrespective of hypothermia. Hippocampal volumes and MB atrophy were associated with total and performance IQ, processing speed and episodic memory in both groups. Normal MB and larger hippocampi were positively associated with global fractional anisotropy. In conclusion, injury to the MB and hippocampi was associated with neurocognition and memory at school-age in HIE and might be an early biomarker for neurocognitive and memory problems.Kim V. AnninkLinda S. de VriesFloris GroenendaalRian M. J. C. EijsermansManouk MockingMonique M. J. van SchooneveldJeroen DudinkHenrica L. M. van StraatenManon J. N. L. BendersMaarten LequinNiek E. van der AaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kim V. Annink Linda S. de Vries Floris Groenendaal Rian M. J. C. Eijsermans Manouk Mocking Monique M. J. van Schooneveld Jeroen Dudink Henrica L. M. van Straaten Manon J. N. L. Benders Maarten Lequin Niek E. van der Aa Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy
description	Abstract The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE with and without therapeutic hypothermia. Additional aims were to assess the associations between MB atrophy, brain volumes (including the hippocampi), white matter microstructure and neurodevelopmental outcome at school-age. Ten-year-old children with HIE were included, who were treated with therapeutic hypothermia (n = 22) or would have qualified but were born before this became standard of care (n = 28). Children completed a neuropsychological and motor assessment and MRI. Mammillary bodies were scored as normal or atrophic at 10 years. Brain volumes were segmented on childhood MRI and DTI scans were analysed using tract-based spatial statistics. Children with HIE suffered from neurocognitive and memory problems at school-age, irrespective of hypothermia. Hippocampal volumes and MB atrophy were associated with total and performance IQ, processing speed and episodic memory in both groups. Normal MB and larger hippocampi were positively associated with global fractional anisotropy. In conclusion, injury to the MB and hippocampi was associated with neurocognition and memory at school-age in HIE and might be an early biomarker for neurocognitive and memory problems.
format	article
author	Kim V. Annink Linda S. de Vries Floris Groenendaal Rian M. J. C. Eijsermans Manouk Mocking Monique M. J. van Schooneveld Jeroen Dudink Henrica L. M. van Straaten Manon J. N. L. Benders Maarten Lequin Niek E. van der Aa
author_facet	Kim V. Annink Linda S. de Vries Floris Groenendaal Rian M. J. C. Eijsermans Manouk Mocking Monique M. J. van Schooneveld Jeroen Dudink Henrica L. M. van Straaten Manon J. N. L. Benders Maarten Lequin Niek E. van der Aa
author_sort	Kim V. Annink
title	Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy
title_short	Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy
title_full	Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy
title_fullStr	Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy
title_full_unstemmed	Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy
title_sort	mammillary body atrophy and other mri correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f8daa1133c2b46cb8a2bc14dabf7dc00
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Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy

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