Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam

Linh Vu Phuong Dang,1 Viet Hung Pham,2 Duc Minh Nguyen,3 Thanh Thi Dinh,1 Thu Hoai Nguyen,4 Thanh Hai Le,5 Van Lam Nguyen,6 Thi Phuong Vu7,8 1Public Health Laboratory, Hanoi University of Public Health, Hanoi, Vietnam; 2Department of Microbiology, Vietnam National Hospital of Pediatrics, Hanoi, Viet...

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Autores principales:	Dang LVP, Pham VH, Nguyen DM, Dinh TT, Nguyen TH, Le TH, Nguyen VL, Vu TP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Antiretroviral therapy HIV-1 immunoglobulin IgG IgA treatment failure Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f8dfe1e5c23143febf0dc1e182b9efc1
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spelling	oai:doaj.org-article:f8dfe1e5c23143febf0dc1e182b9efc12021-12-02T09:23:34ZElevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam1179-1373https://doaj.org/article/f8dfe1e5c23143febf0dc1e182b9efc12018-12-01T00:00:00Zhttps://www.dovepress.com/elevation-of-immunoglobulin-levels-is-associated-with-treatment-failur-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Linh Vu Phuong Dang,1 Viet Hung Pham,2 Duc Minh Nguyen,3 Thanh Thi Dinh,1 Thu Hoai Nguyen,4 Thanh Hai Le,5 Van Lam Nguyen,6 Thi Phuong Vu7,8 1Public Health Laboratory, Hanoi University of Public Health, Hanoi, Vietnam; 2Department of Microbiology, Vietnam National Hospital of Pediatrics, Hanoi, Vietnam; 3Department of Geriatrics, National Hospital of Acupuncture, Hanoi, Vietnam; 4Department of Training and Direction Activity, National Geriatric Hospital, Hanoi, Vietnam; 5Department of Emergency, Vietnam National Hospital of Pediatrics, Hanoi, Vietnam; 6Department of Infectious Disease, Vietnam National Hospital of Pediatrics, Hanoi, Vietnam; 7Department of Biochemistry, Hanoi Medical University, Hanoi, Vietnam; 8Department of Biochemistry, Dinh Tien Hoang Institute of Medicine, Hanoi, Vietnam Background: HIV-infected children suffer from higher levels of treatment failure compared to adults. Immunoactivation, including humoral immunoactivation reflected by increased immunoglobulin levels, is believed to occur early during HIV infection. Therefore, we wanted investigate alteration in immunoglobulin levels in association with treatment response in HIV-infected children. Methods: A nested case–control study was conducted using clinical data collected from 68 HIV-infected children enrolled at the National Hospital of Pediatrics, Vietnam. Results: The results showed that immunoglobulin levels, CD4 T-cell counts, CD4 T-cell percentage, and HIV load were significantly higher in the treatment-failure group than the treatment-success group at treatment initiation. IgG and IgA levels were negatively correlated with CD4 T-cell counts (P=0.049 and P<0.01, respectively) and positively correlated with HIV load (P=0.04 and P=0.02, respectively). In addition, IgG and IgA levels were independently associated with treatment response, analyzed by Cox regression analysis (HR 1.19 [P=0.049] and HR 1.69 [P<0.01], respectively). Conclusion: Elevation of IgA levels occurred early during HIV infection, and might have a prognostic role in treatment response. Keywords: antiretroviral therapy, HIV1, immunoglobulin, IgG, IgA, treatment failureDang LVPPham VHNguyen DMDinh TTNguyen THLe THNguyen VLVu TPDove Medical PressarticleAntiretroviral therapyHIV-1immunoglobulinIgGIgAtreatment failureImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 11, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antiretroviral therapy HIV-1 immunoglobulin IgG IgA treatment failure Immunologic diseases. Allergy RC581-607
spellingShingle	Antiretroviral therapy HIV-1 immunoglobulin IgG IgA treatment failure Immunologic diseases. Allergy RC581-607 Dang LVP Pham VH Nguyen DM Dinh TT Nguyen TH Le TH Nguyen VL Vu TP Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam
description	Linh Vu Phuong Dang,1 Viet Hung Pham,2 Duc Minh Nguyen,3 Thanh Thi Dinh,1 Thu Hoai Nguyen,4 Thanh Hai Le,5 Van Lam Nguyen,6 Thi Phuong Vu7,8 1Public Health Laboratory, Hanoi University of Public Health, Hanoi, Vietnam; 2Department of Microbiology, Vietnam National Hospital of Pediatrics, Hanoi, Vietnam; 3Department of Geriatrics, National Hospital of Acupuncture, Hanoi, Vietnam; 4Department of Training and Direction Activity, National Geriatric Hospital, Hanoi, Vietnam; 5Department of Emergency, Vietnam National Hospital of Pediatrics, Hanoi, Vietnam; 6Department of Infectious Disease, Vietnam National Hospital of Pediatrics, Hanoi, Vietnam; 7Department of Biochemistry, Hanoi Medical University, Hanoi, Vietnam; 8Department of Biochemistry, Dinh Tien Hoang Institute of Medicine, Hanoi, Vietnam Background: HIV-infected children suffer from higher levels of treatment failure compared to adults. Immunoactivation, including humoral immunoactivation reflected by increased immunoglobulin levels, is believed to occur early during HIV infection. Therefore, we wanted investigate alteration in immunoglobulin levels in association with treatment response in HIV-infected children. Methods: A nested case–control study was conducted using clinical data collected from 68 HIV-infected children enrolled at the National Hospital of Pediatrics, Vietnam. Results: The results showed that immunoglobulin levels, CD4 T-cell counts, CD4 T-cell percentage, and HIV load were significantly higher in the treatment-failure group than the treatment-success group at treatment initiation. IgG and IgA levels were negatively correlated with CD4 T-cell counts (P=0.049 and P<0.01, respectively) and positively correlated with HIV load (P=0.04 and P=0.02, respectively). In addition, IgG and IgA levels were independently associated with treatment response, analyzed by Cox regression analysis (HR 1.19 [P=0.049] and HR 1.69 [P<0.01], respectively). Conclusion: Elevation of IgA levels occurred early during HIV infection, and might have a prognostic role in treatment response. Keywords: antiretroviral therapy, HIV1, immunoglobulin, IgG, IgA, treatment failure
format	article
author	Dang LVP Pham VH Nguyen DM Dinh TT Nguyen TH Le TH Nguyen VL Vu TP
author_facet	Dang LVP Pham VH Nguyen DM Dinh TT Nguyen TH Le TH Nguyen VL Vu TP
author_sort	Dang LVP
title	Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam
title_short	Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam
title_full	Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam
title_fullStr	Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam
title_full_unstemmed	Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam
title_sort	elevation of immunoglobulin levels is associated with treatment failure in hiv-infected children in vietnam
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f8dfe1e5c23143febf0dc1e182b9efc1
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Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam

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