MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION

Immunophenotypic and morphological peculiarities of immune reactions under intranasal, peroral and subcutaneous introduction of multicomponent vaccine Immunovac VP-4 containing a group of opportunistic bacterial antigens were investigated. The investigated preparation was found to cause marked activ...

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Autores principales:	O. V. Lebedinskaya, N. K. Akhmatova, M. B. Brodovsky, E. A. Ilinykh, N. B. Egorova, E. A. Kurbatova, S. V. Melekhin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	mucosal immunity immunovac vp-4 immunophenotype morphological changes mucosal immunization parenteral immunization Science Q
Acceso en línea:	https://doaj.org/article/f8e3711078ce4c4da3d3cc2ea3b8939f
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spelling	oai:doaj.org-article:f8e3711078ce4c4da3d3cc2ea3b8939f2021-11-23T06:14:20ZMORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION2541-94202587-9596https://doaj.org/article/f8e3711078ce4c4da3d3cc2ea3b8939f2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/937https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Immunophenotypic and morphological peculiarities of immune reactions under intranasal, peroral and subcutaneous introduction of multicomponent vaccine Immunovac VP-4 containing a group of opportunistic bacterial antigens were investigated. The investigated preparation was found to cause marked activation of congenital immunity effectors both in parenteral and mucosal immunization. It is manifested in the expression of differential, costimulatory, adhesive molecules on the surface of mononuclear leukocytes in proliferation of key mucosal immunity effectors (γδТ, В1, NK cells), and changes in structure, cellular composition of immunocompetent organs both regional and distant as to the site of introduction. Currently existing data on effects and mechanisms of vaccine and immunomodulator mucosal introduction allows considering the development of mucosal mono- and associated vaccines as the priority direction in modern vaccinology.O. V. LebedinskayaN. K. AkhmatovaM. B. BrodovskyE. A. IlinykhN. B. EgorovaE. A. KurbatovaS. V. MelekhinScientific Сentre for Family Health and Human Reproduction Problemsarticlemucosal immunityimmunovac vp-4immunophenotypemorphological changesmucosal immunizationparenteral immunizationScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 288-295 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	mucosal immunity immunovac vp-4 immunophenotype morphological changes mucosal immunization parenteral immunization Science Q
spellingShingle	mucosal immunity immunovac vp-4 immunophenotype morphological changes mucosal immunization parenteral immunization Science Q O. V. Lebedinskaya N. K. Akhmatova M. B. Brodovsky E. A. Ilinykh N. B. Egorova E. A. Kurbatova S. V. Melekhin MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
description	Immunophenotypic and morphological peculiarities of immune reactions under intranasal, peroral and subcutaneous introduction of multicomponent vaccine Immunovac VP-4 containing a group of opportunistic bacterial antigens were investigated. The investigated preparation was found to cause marked activation of congenital immunity effectors both in parenteral and mucosal immunization. It is manifested in the expression of differential, costimulatory, adhesive molecules on the surface of mononuclear leukocytes in proliferation of key mucosal immunity effectors (γδТ, В1, NK cells), and changes in structure, cellular composition of immunocompetent organs both regional and distant as to the site of introduction. Currently existing data on effects and mechanisms of vaccine and immunomodulator mucosal introduction allows considering the development of mucosal mono- and associated vaccines as the priority direction in modern vaccinology.
format	article
author	O. V. Lebedinskaya N. K. Akhmatova M. B. Brodovsky E. A. Ilinykh N. B. Egorova E. A. Kurbatova S. V. Melekhin
author_facet	O. V. Lebedinskaya N. K. Akhmatova M. B. Brodovsky E. A. Ilinykh N. B. Egorova E. A. Kurbatova S. V. Melekhin
author_sort	O. V. Lebedinskaya
title	MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_short	MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_full	MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_fullStr	MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_full_unstemmed	MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_sort	morphofunctional peculiarities of mucosal immunity depending on methods of opportunistic microbial introduction
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/f8e3711078ce4c4da3d3cc2ea3b8939f
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MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION

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