A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile

Abstract Several epidemiologic studies have evaluated the relation between serum/plasma brain-derived neurotrophic factor (BDNF) levels and glycemic parameters, but the findings were conflicting. We performed a systematic review and meta-analysis to compare circulating BDNF levels in individuals wit...

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Autores principales:	Milad Davarpanah, Nafiseh Shokri-mashhadi, Rahele Ziaei, Parvane Saneei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8e3b9563b3843bd93b0f2426ae14d77
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spelling	oai:doaj.org-article:f8e3b9563b3843bd93b0f2426ae14d772021-12-02T14:33:57ZA systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile10.1038/s41598-021-93271-z2045-2322https://doaj.org/article/f8e3b9563b3843bd93b0f2426ae14d772021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93271-zhttps://doaj.org/toc/2045-2322Abstract Several epidemiologic studies have evaluated the relation between serum/plasma brain-derived neurotrophic factor (BDNF) levels and glycemic parameters, but the findings were conflicting. We performed a systematic review and meta-analysis to compare circulating BDNF levels in individuals with type 2 diabetes (T2D) or other glycemic disorders with healthy controls and to evaluate correlation between BDNF concentrations with glycemic profile. A systematic search up to July 2020 was conducted in reliable electronic databases (MEDLINE (Pubmed), EMBASE, Scopus) and Google scholar. Sixteen observational studies compared serum/plasma BDNF levels in diabetic patients (or individuals with glycemic disorders) vs. healthy controls or reported correlations between serum BDNF levels and glycemic parameters in adults were included in the review. Overall weighted mean difference (WMD) of circulating BDNF levels in 1306 patients with T2D (or other glycemic disorders) was 1.12 ng/mL lower than 1250 healthy subjects (WMD: − 1.12; 95%CI − 1.37, − 0.88, I2 = 98.7%, P < 0.001). Subgroup analysis revealed that both diabetic patients and subjects with other glycemic disorders had lower serum/plasma BDNF levels than healthy controls (WMD: − 1.74; 95%CI − 2.15, − 1.33 and WMD: − 0.49; 95%CI − 0.82, − 0.16, respectively). No significant correlation was found between BDNF levels and glycemic parameters [fasting blood glucose (FBG) (Fisher’s Z = 0.05; 95%CI − 0.21, 0.11; n = 1400), homeostatic model assessment for insulin resistance (HOMA-IR) (Fisher’s Z = 0.12; 95%CI − 0.20, 0.44; n = 732) and glycosylated hemoglobin (HbA1c) (Fisher’s Z = 0.04; 95%CI − 0.05, 0.12; n = 2222)]. We found that diabetic patients and subjects with glycemic disorders had lower circulating BDNF levels than healthy controls. However, there was no significant correlation between BDNF concentrations and glycemic parameters including FBG, HOMA-IR and HbA1c. Further prospective investigations are required to confirm these findings.Milad DavarpanahNafiseh Shokri-mashhadiRahele ZiaeiParvane SaneeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Milad Davarpanah Nafiseh Shokri-mashhadi Rahele Ziaei Parvane Saneei A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile
description	Abstract Several epidemiologic studies have evaluated the relation between serum/plasma brain-derived neurotrophic factor (BDNF) levels and glycemic parameters, but the findings were conflicting. We performed a systematic review and meta-analysis to compare circulating BDNF levels in individuals with type 2 diabetes (T2D) or other glycemic disorders with healthy controls and to evaluate correlation between BDNF concentrations with glycemic profile. A systematic search up to July 2020 was conducted in reliable electronic databases (MEDLINE (Pubmed), EMBASE, Scopus) and Google scholar. Sixteen observational studies compared serum/plasma BDNF levels in diabetic patients (or individuals with glycemic disorders) vs. healthy controls or reported correlations between serum BDNF levels and glycemic parameters in adults were included in the review. Overall weighted mean difference (WMD) of circulating BDNF levels in 1306 patients with T2D (or other glycemic disorders) was 1.12 ng/mL lower than 1250 healthy subjects (WMD: − 1.12; 95%CI − 1.37, − 0.88, I2 = 98.7%, P < 0.001). Subgroup analysis revealed that both diabetic patients and subjects with other glycemic disorders had lower serum/plasma BDNF levels than healthy controls (WMD: − 1.74; 95%CI − 2.15, − 1.33 and WMD: − 0.49; 95%CI − 0.82, − 0.16, respectively). No significant correlation was found between BDNF levels and glycemic parameters [fasting blood glucose (FBG) (Fisher’s Z = 0.05; 95%CI − 0.21, 0.11; n = 1400), homeostatic model assessment for insulin resistance (HOMA-IR) (Fisher’s Z = 0.12; 95%CI − 0.20, 0.44; n = 732) and glycosylated hemoglobin (HbA1c) (Fisher’s Z = 0.04; 95%CI − 0.05, 0.12; n = 2222)]. We found that diabetic patients and subjects with glycemic disorders had lower circulating BDNF levels than healthy controls. However, there was no significant correlation between BDNF concentrations and glycemic parameters including FBG, HOMA-IR and HbA1c. Further prospective investigations are required to confirm these findings.
format	article
author	Milad Davarpanah Nafiseh Shokri-mashhadi Rahele Ziaei Parvane Saneei
author_facet	Milad Davarpanah Nafiseh Shokri-mashhadi Rahele Ziaei Parvane Saneei
author_sort	Milad Davarpanah
title	A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile
title_short	A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile
title_full	A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile
title_fullStr	A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile
title_full_unstemmed	A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile
title_sort	systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f8e3b9563b3843bd93b0f2426ae14d77
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A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile

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