Changes in oral flora of patients with functional dyspepsia

Abstract To explore the changes in oral flora in people with functional dyspepsia (FD). Unstimulated saliva was collected from 21 FD patients diagnosed according to the Rome IV criteria and from 12 healthy controls (HCs) for 16SrRNA sequencing. The pH of saliva samples and community periodontal inde...

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Autores principales:	Xu-juan Liu, Wen-rui Xie, Li-hao Wu, Zhi-ning Ye, Xue-yuan Zhang, Ran Zhang, Xing-xiang He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8eb53cf5ed649cdad0af98ce1548ea2
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spelling	oai:doaj.org-article:f8eb53cf5ed649cdad0af98ce1548ea22021-12-02T15:51:16ZChanges in oral flora of patients with functional dyspepsia10.1038/s41598-021-87600-52045-2322https://doaj.org/article/f8eb53cf5ed649cdad0af98ce1548ea22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87600-5https://doaj.org/toc/2045-2322Abstract To explore the changes in oral flora in people with functional dyspepsia (FD). Unstimulated saliva was collected from 21 FD patients diagnosed according to the Rome IV criteria and from 12 healthy controls (HCs) for 16SrRNA sequencing. The pH of saliva samples and community periodontal index (CPI) were tested. The prevalence of small intestinal bacterial overgrowth (SIBO) was obtained by the methane-and hydrogen-based breath test. At the phylum level, FD patients had a higher relative abundance of Spirochaetes and a lower relative abundance of Fusobacteria, TM7 and Proteobacteria than HCs (p < 0.01). In the saliva, Kingella and Abiotrophia genus levels showed significant changes between the FD and HC groups (p < 0.01). Salivary species level marker Intermedia was significantly different between FD and HC groups (p < 0.01). The oral pH of FD patients was higher than that of HCs (p < 0.01). The mean CPI of the FD group was 1.52 and that of the HC group was 0.17 (p < 0.01). Moreover, 71.4% of the FD group was positive for SIBO. The oral flora of FD patients was different from that of HCs. Spirochaetes, Kingella, Abiotrophia, and Intermedia may be diagnostic indicators of FD.Xu-juan LiuWen-rui XieLi-hao WuZhi-ning YeXue-yuan ZhangRan ZhangXing-xiang HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xu-juan Liu Wen-rui Xie Li-hao Wu Zhi-ning Ye Xue-yuan Zhang Ran Zhang Xing-xiang He Changes in oral flora of patients with functional dyspepsia
description	Abstract To explore the changes in oral flora in people with functional dyspepsia (FD). Unstimulated saliva was collected from 21 FD patients diagnosed according to the Rome IV criteria and from 12 healthy controls (HCs) for 16SrRNA sequencing. The pH of saliva samples and community periodontal index (CPI) were tested. The prevalence of small intestinal bacterial overgrowth (SIBO) was obtained by the methane-and hydrogen-based breath test. At the phylum level, FD patients had a higher relative abundance of Spirochaetes and a lower relative abundance of Fusobacteria, TM7 and Proteobacteria than HCs (p < 0.01). In the saliva, Kingella and Abiotrophia genus levels showed significant changes between the FD and HC groups (p < 0.01). Salivary species level marker Intermedia was significantly different between FD and HC groups (p < 0.01). The oral pH of FD patients was higher than that of HCs (p < 0.01). The mean CPI of the FD group was 1.52 and that of the HC group was 0.17 (p < 0.01). Moreover, 71.4% of the FD group was positive for SIBO. The oral flora of FD patients was different from that of HCs. Spirochaetes, Kingella, Abiotrophia, and Intermedia may be diagnostic indicators of FD.
format	article
author	Xu-juan Liu Wen-rui Xie Li-hao Wu Zhi-ning Ye Xue-yuan Zhang Ran Zhang Xing-xiang He
author_facet	Xu-juan Liu Wen-rui Xie Li-hao Wu Zhi-ning Ye Xue-yuan Zhang Ran Zhang Xing-xiang He
author_sort	Xu-juan Liu
title	Changes in oral flora of patients with functional dyspepsia
title_short	Changes in oral flora of patients with functional dyspepsia
title_full	Changes in oral flora of patients with functional dyspepsia
title_fullStr	Changes in oral flora of patients with functional dyspepsia
title_full_unstemmed	Changes in oral flora of patients with functional dyspepsia
title_sort	changes in oral flora of patients with functional dyspepsia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f8eb53cf5ed649cdad0af98ce1548ea2
work_keys_str_mv	AT xujuanliu changesinoralfloraofpatientswithfunctionaldyspepsia AT wenruixie changesinoralfloraofpatientswithfunctionaldyspepsia AT lihaowu changesinoralfloraofpatientswithfunctionaldyspepsia AT zhiningye changesinoralfloraofpatientswithfunctionaldyspepsia AT xueyuanzhang changesinoralfloraofpatientswithfunctionaldyspepsia AT ranzhang changesinoralfloraofpatientswithfunctionaldyspepsia AT xingxianghe changesinoralfloraofpatientswithfunctionaldyspepsia
_version_	1718385607475986432

Changes in oral flora of patients with functional dyspepsia

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