Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation

Yao Yao et al. perform transcriptome-wide association analysis through integration of gene expression data and results of a previously-published genome-wide association study for neutrophil count. They find 34 independent genomic regions associated with expression changes and show that knockout of o...

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Autores principales:	Yao Yao, Jia Yang, Qian Qin, Chao Tang, Zhidan Li, Li Chen, Kailong Li, Chunyan Ren, Lu Chen, Shuquan Rao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f8ebbe48549f495c8181e46ae68dc1e1
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spelling	oai:doaj.org-article:f8ebbe48549f495c8181e46ae68dc1e12021-12-02T12:40:39ZFunctional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation10.1038/s42003-020-01527-72399-3642https://doaj.org/article/f8ebbe48549f495c8181e46ae68dc1e12020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01527-7https://doaj.org/toc/2399-3642Yao Yao et al. perform transcriptome-wide association analysis through integration of gene expression data and results of a previously-published genome-wide association study for neutrophil count. They find 34 independent genomic regions associated with expression changes and show that knockout of one candidate gene, TAF9, in CD34+ progenitor cells increases neutrophil maturation in vitro.Yao YaoJia YangQian QinChao TangZhidan LiLi ChenKailong LiChunyan RenLu ChenShuquan RaoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yao Yao Jia Yang Qian Qin Chao Tang Zhidan Li Li Chen Kailong Li Chunyan Ren Lu Chen Shuquan Rao Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation
description	Yao Yao et al. perform transcriptome-wide association analysis through integration of gene expression data and results of a previously-published genome-wide association study for neutrophil count. They find 34 independent genomic regions associated with expression changes and show that knockout of one candidate gene, TAF9, in CD34+ progenitor cells increases neutrophil maturation in vitro.
format	article
author	Yao Yao Jia Yang Qian Qin Chao Tang Zhidan Li Li Chen Kailong Li Chunyan Ren Lu Chen Shuquan Rao
author_facet	Yao Yao Jia Yang Qian Qin Chao Tang Zhidan Li Li Chen Kailong Li Chunyan Ren Lu Chen Shuquan Rao
author_sort	Yao Yao
title	Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation
title_short	Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation
title_full	Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation
title_fullStr	Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation
title_full_unstemmed	Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation
title_sort	functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f8ebbe48549f495c8181e46ae68dc1e1
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Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation

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