Drug Design: Where We Are and Future Prospects

Medicinal chemistry is facing new challenges in approaching precision medicine. Several powerful new tools or improvements of already used tools are now available to medicinal chemists to help in the process of drug discovery, from a hit molecule to a clinically used drug. Among the new tools, the p...

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Autores principales:	Giuseppe Zagotto, Marco Bortoli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug discovery precision medicine pharmacodynamics pharmacokinetics Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/f8ec789563cf48f1a37e870e8109bc0e
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id	oai:doaj.org-article:f8ec789563cf48f1a37e870e8109bc0e
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spelling	oai:doaj.org-article:f8ec789563cf48f1a37e870e8109bc0e2021-11-25T18:29:31ZDrug Design: Where We Are and Future Prospects10.3390/molecules262270611420-3049https://doaj.org/article/f8ec789563cf48f1a37e870e8109bc0e2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/7061https://doaj.org/toc/1420-3049Medicinal chemistry is facing new challenges in approaching precision medicine. Several powerful new tools or improvements of already used tools are now available to medicinal chemists to help in the process of drug discovery, from a hit molecule to a clinically used drug. Among the new tools, the possibility of considering folding intermediates or the catalytic process of a protein as a target for discovering new hits has emerged. In addition, machine learning is a new valuable approach helping medicinal chemists to discover new hits. Other abilities, ranging from the better understanding of the time evolution of biochemical processes to the comprehension of the biological meaning of the data originated from genetic analyses, are on their way to progress further in the drug discovery field toward improved patient care. In this sense, the new approaches to the delivery of drugs targeted to the central nervous system, together with the advancements in understanding the metabolic pathways for a growing number of drugs and relating them to the genetic characteristics of patients, constitute important progress in the field.Giuseppe ZagottoMarco BortoliMDPI AGarticledrug discoveryprecision medicinepharmacodynamicspharmacokineticsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 7061, p 7061 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug discovery precision medicine pharmacodynamics pharmacokinetics Organic chemistry QD241-441
spellingShingle	drug discovery precision medicine pharmacodynamics pharmacokinetics Organic chemistry QD241-441 Giuseppe Zagotto Marco Bortoli Drug Design: Where We Are and Future Prospects
description	Medicinal chemistry is facing new challenges in approaching precision medicine. Several powerful new tools or improvements of already used tools are now available to medicinal chemists to help in the process of drug discovery, from a hit molecule to a clinically used drug. Among the new tools, the possibility of considering folding intermediates or the catalytic process of a protein as a target for discovering new hits has emerged. In addition, machine learning is a new valuable approach helping medicinal chemists to discover new hits. Other abilities, ranging from the better understanding of the time evolution of biochemical processes to the comprehension of the biological meaning of the data originated from genetic analyses, are on their way to progress further in the drug discovery field toward improved patient care. In this sense, the new approaches to the delivery of drugs targeted to the central nervous system, together with the advancements in understanding the metabolic pathways for a growing number of drugs and relating them to the genetic characteristics of patients, constitute important progress in the field.
format	article
author	Giuseppe Zagotto Marco Bortoli
author_facet	Giuseppe Zagotto Marco Bortoli
author_sort	Giuseppe Zagotto
title	Drug Design: Where We Are and Future Prospects
title_short	Drug Design: Where We Are and Future Prospects
title_full	Drug Design: Where We Are and Future Prospects
title_fullStr	Drug Design: Where We Are and Future Prospects
title_full_unstemmed	Drug Design: Where We Are and Future Prospects
title_sort	drug design: where we are and future prospects
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f8ec789563cf48f1a37e870e8109bc0e
work_keys_str_mv	AT giuseppezagotto drugdesignwhereweareandfutureprospects AT marcobortoli drugdesignwhereweareandfutureprospects
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Drug Design: Where We Are and Future Prospects

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