Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone

Hong Liu-Seifert1, Bruce J Kinon1, Christopher J Tennant2, Jennifer Sniadecki1, Jan Volavka31Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA; 2CJT Biomedical Consulting, South Lake Tahoe, CA, USA; 3New York University, New York, NY, USAObjective: To...

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Autores principales:	Hong Liu-Seifert, Bruce J Kinon, Christopher J Tennant, Jennifer Sniadecki, Jan Volavka
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f8f07dff813c429bb02e706763cc4764
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spelling	oai:doaj.org-article:f8f07dff813c429bb02e706763cc47642021-12-02T07:45:45ZSexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone1176-63281178-2021https://doaj.org/article/f8f07dff813c429bb02e706763cc47642009-01-01T00:00:00Zhttp://www.dovepress.com/sexual-dysfunction-in-patients-with-schizophrenia-treated-with-convent-a2814https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Hong Liu-Seifert1, Bruce J Kinon1, Christopher J Tennant2, Jennifer Sniadecki1, Jan Volavka31Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA; 2CJT Biomedical Consulting, South Lake Tahoe, CA, USA; 3New York University, New York, NY, USAObjective: To better understand sexual dysfunction in patients with schizophrenia and its associations with prolactin and reproductive hormones.Methods: This was a secondary analysis of an open-label, one-day study (N = 402). The primary objective of the study was to assess the prevalence of hyperprolactinemia in patients with schizophrenia who had been treated with conventional antipsychotics or risperidone. Other atypical antipsychotics available at the time of the study were not included due to a more favorable prolactin profile.Results: The majority of patients (59% of females and 60% of males) reported impairment of sexual function. In postmenopausal females, risk of impaired sexual interest was increased by 31% for every 10 ng/ml increase in prolactin (p = 0.035). In males, lower testosterone was associated with higher prolactin (p &lt;&nbsp;0.001) and with orgasmic (p = 0.004) and ejaculatory dysfunction (p = 0.028).Conclusion: These findings suggest that hyperprolactinemia may be associated with sexual dysfunction. They also provide more information on the relationships between prolactin, reproductive hormones, and sexual dysfunction. Sexual dysfunction is an understudied yet important consideration in the treatment of schizophrenia. More attention is warranted in this area as it may provide opportunities for improved quality of life and adherence to treatment for patients.Keywords: sexual dysfunction, schizophrenia, hyperprolactinemia, antipsychotics, risperidone Hong Liu-SeifertBruce J KinonChristopher J TennantJennifer SniadeckiJan VolavkaDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 47-54 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hong Liu-Seifert Bruce J Kinon Christopher J Tennant Jennifer Sniadecki Jan Volavka Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone
description	Hong Liu-Seifert1, Bruce J Kinon1, Christopher J Tennant2, Jennifer Sniadecki1, Jan Volavka31Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA; 2CJT Biomedical Consulting, South Lake Tahoe, CA, USA; 3New York University, New York, NY, USAObjective: To better understand sexual dysfunction in patients with schizophrenia and its associations with prolactin and reproductive hormones.Methods: This was a secondary analysis of an open-label, one-day study (N = 402). The primary objective of the study was to assess the prevalence of hyperprolactinemia in patients with schizophrenia who had been treated with conventional antipsychotics or risperidone. Other atypical antipsychotics available at the time of the study were not included due to a more favorable prolactin profile.Results: The majority of patients (59% of females and 60% of males) reported impairment of sexual function. In postmenopausal females, risk of impaired sexual interest was increased by 31% for every 10 ng/ml increase in prolactin (p = 0.035). In males, lower testosterone was associated with higher prolactin (p &lt;&nbsp;0.001) and with orgasmic (p = 0.004) and ejaculatory dysfunction (p = 0.028).Conclusion: These findings suggest that hyperprolactinemia may be associated with sexual dysfunction. They also provide more information on the relationships between prolactin, reproductive hormones, and sexual dysfunction. Sexual dysfunction is an understudied yet important consideration in the treatment of schizophrenia. More attention is warranted in this area as it may provide opportunities for improved quality of life and adherence to treatment for patients.Keywords: sexual dysfunction, schizophrenia, hyperprolactinemia, antipsychotics, risperidone
format	article
author	Hong Liu-Seifert Bruce J Kinon Christopher J Tennant Jennifer Sniadecki Jan Volavka
author_facet	Hong Liu-Seifert Bruce J Kinon Christopher J Tennant Jennifer Sniadecki Jan Volavka
author_sort	Hong Liu-Seifert
title	Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone
title_short	Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone
title_full	Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone
title_fullStr	Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone
title_full_unstemmed	Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone
title_sort	sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/f8f07dff813c429bb02e706763cc4764
work_keys_str_mv	AT hongliuseifert sexualdysfunctioninpatientswithschizophreniatreatedwithconventionalantipsychoticsorrisperidone AT brucejkinon sexualdysfunctioninpatientswithschizophreniatreatedwithconventionalantipsychoticsorrisperidone AT christopherjtennant sexualdysfunctioninpatientswithschizophreniatreatedwithconventionalantipsychoticsorrisperidone AT jennifersniadecki sexualdysfunctioninpatientswithschizophreniatreatedwithconventionalantipsychoticsorrisperidone AT janvolavka sexualdysfunctioninpatientswithschizophreniatreatedwithconventionalantipsychoticsorrisperidone
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Sexual dysfunction in patients with schizophrenia treated with conventional antipsychotics or risperidone

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