Salivary cortisol is associated with cognitive changes in patients with fibromyalgia

Abstract Fibromyalgia (FM) is a stress-related chronic pain disorder with common cognitive complaints. This study characterized cognitive dysfunction in patients with FM and explored whether these changes are linked to altered cortisol levels. Consecutive 44 patients with FM and 48 healthy controls...

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Autores principales:	Yi-Ju Lin, Yu-Chieh Ko, Lok-Hi Chow, Fu-Jung Hsiao, Hung-Yu Liu, Pei-Ning Wang, Wei-Ta Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8f0abf0250b498697bf90a5828da1e3
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spelling	oai:doaj.org-article:f8f0abf0250b498697bf90a5828da1e32021-12-02T14:12:08ZSalivary cortisol is associated with cognitive changes in patients with fibromyalgia10.1038/s41598-020-79349-02045-2322https://doaj.org/article/f8f0abf0250b498697bf90a5828da1e32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79349-0https://doaj.org/toc/2045-2322Abstract Fibromyalgia (FM) is a stress-related chronic pain disorder with common cognitive complaints. This study characterized cognitive dysfunction in patients with FM and explored whether these changes are linked to altered cortisol levels. Consecutive 44 patients with FM and 48 healthy controls were enrolled for the assessments of subjective and objective cognitive functions and diurnal levels of salivary cortisol (sampled at awakening, 30 min after awakening, 3 pm, and bedtime). All measurements were compared between the groups and evaluated for clinical correlation. The FM group had more subjective cognitive complaints and performed poorer in objective cognitive testing in memory (delayed recall in Chinese Version Verbal Learning Test and Taylor Complex Figure Test), language (Boston Naming Test), and executive domains (Wisconsin Card Sorting Test) after adjustments for education. The diurnal cortisol levels of patients with FM tended to be lower, especially at 30 min after awakening and bedtime. Moreover, moderate positive correlations existed between the Chinese Version Verbal Learning Test, Boston Naming Test and the morning cortisol levels within the FM group. We suggested the altered cognitive function in FM may be linked to stress maladaptation. Future studies are warranted to elucidate whether stress management improves cognitive performance in patients with FM.Yi-Ju LinYu-Chieh KoLok-Hi ChowFu-Jung HsiaoHung-Yu LiuPei-Ning WangWei-Ta ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Ju Lin Yu-Chieh Ko Lok-Hi Chow Fu-Jung Hsiao Hung-Yu Liu Pei-Ning Wang Wei-Ta Chen Salivary cortisol is associated with cognitive changes in patients with fibromyalgia
description	Abstract Fibromyalgia (FM) is a stress-related chronic pain disorder with common cognitive complaints. This study characterized cognitive dysfunction in patients with FM and explored whether these changes are linked to altered cortisol levels. Consecutive 44 patients with FM and 48 healthy controls were enrolled for the assessments of subjective and objective cognitive functions and diurnal levels of salivary cortisol (sampled at awakening, 30 min after awakening, 3 pm, and bedtime). All measurements were compared between the groups and evaluated for clinical correlation. The FM group had more subjective cognitive complaints and performed poorer in objective cognitive testing in memory (delayed recall in Chinese Version Verbal Learning Test and Taylor Complex Figure Test), language (Boston Naming Test), and executive domains (Wisconsin Card Sorting Test) after adjustments for education. The diurnal cortisol levels of patients with FM tended to be lower, especially at 30 min after awakening and bedtime. Moreover, moderate positive correlations existed between the Chinese Version Verbal Learning Test, Boston Naming Test and the morning cortisol levels within the FM group. We suggested the altered cognitive function in FM may be linked to stress maladaptation. Future studies are warranted to elucidate whether stress management improves cognitive performance in patients with FM.
format	article
author	Yi-Ju Lin Yu-Chieh Ko Lok-Hi Chow Fu-Jung Hsiao Hung-Yu Liu Pei-Ning Wang Wei-Ta Chen
author_facet	Yi-Ju Lin Yu-Chieh Ko Lok-Hi Chow Fu-Jung Hsiao Hung-Yu Liu Pei-Ning Wang Wei-Ta Chen
author_sort	Yi-Ju Lin
title	Salivary cortisol is associated with cognitive changes in patients with fibromyalgia
title_short	Salivary cortisol is associated with cognitive changes in patients with fibromyalgia
title_full	Salivary cortisol is associated with cognitive changes in patients with fibromyalgia
title_fullStr	Salivary cortisol is associated with cognitive changes in patients with fibromyalgia
title_full_unstemmed	Salivary cortisol is associated with cognitive changes in patients with fibromyalgia
title_sort	salivary cortisol is associated with cognitive changes in patients with fibromyalgia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f8f0abf0250b498697bf90a5828da1e3
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Salivary cortisol is associated with cognitive changes in patients with fibromyalgia

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