ASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR

Objective: Children with thalassemia major are prone to growth failure and micronutrient deficiency. In this study, we aimed to evaluate nutritional status, anthropometrics, bone mineralization defects in regularly transfused patients. Methodology: We analyzed the data obtained by evaluating laborat...

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Autores principales:	Serap Cevher Bulğurcu, Aylin Canbolat Ayhan, Hamdi Emeksiz, Fahri Ovalı
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/f8f193168b6e4e2ca35eb74974b224c4
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spelling	oai:doaj.org-article:f8f193168b6e4e2ca35eb74974b224c42021-11-10T04:33:15ZASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR2531-137910.1016/j.htct.2021.10.987https://doaj.org/article/f8f193168b6e4e2ca35eb74974b224c42021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011342https://doaj.org/toc/2531-1379Objective: Children with thalassemia major are prone to growth failure and micronutrient deficiency. In this study, we aimed to evaluate nutritional status, anthropometrics, bone mineralization defects in regularly transfused patients. Methodology: We analyzed the data obtained by evaluating laboratory tests, anthropometric measures, and bone mineral density. Results: Twenty-nine patients (62% male, 38% female) with mean age 12.26±4.74 years, mean pre-transfusion hemoglobin 8.64±1.01 g/dl, mean serum ferritin 1158.6±556.8 ng/ml were included. Vitamin D (72.4%), selenium (72.4%), folate (37.9%) deficiencies were the most frequent ones. In 17.2% hypocalcemia, 3.5% hypomagnesemia, in 10.3 % decreased ceruloplasmin were observed. Folate was higher between 2≤ and<6 years (p:0.028). Ceruloplasmin was higher between 6≤ and<10 years (p:0.018). Selenium was significantly higher in patients with ferritin ≥1500 (p=0.008). No significant ferritin-related differences were found in other micronutrients (p>0.05)For body mass index (BMI) 31% were under the 5th percentile, none was over the 95th percentile. For height, 24.5%, for weight 20.7% were under the 3rd, none was over 97th percentile. BMI of patients 10≤age≤18 years old was significantly higher (p=0.001). Anthropometric percentiles did not differ significantly in terms of mean serum ferritin and micronutrient levels. Hypoparathyroidism was observed in 13.8%, hypothyroidism in 3.5% of the patients. Low bone density was detected in 14.8% (2 osteopenic, 2 osteoporotic) patients. Bone mineral density did not differ significantly in terms of ferritin and micronutrient levels. Conclusions: Nutritional support and prevention of deficiencies are important to minimize the burden of complications, to increase the life expectancy and quality in TM patients.Serap Cevher BulğurcuAylin Canbolat AyhanHamdi EmeksizFahri OvalıElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S23- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Serap Cevher Bulğurcu Aylin Canbolat Ayhan Hamdi Emeksiz Fahri Ovalı ASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR
description	Objective: Children with thalassemia major are prone to growth failure and micronutrient deficiency. In this study, we aimed to evaluate nutritional status, anthropometrics, bone mineralization defects in regularly transfused patients. Methodology: We analyzed the data obtained by evaluating laboratory tests, anthropometric measures, and bone mineral density. Results: Twenty-nine patients (62% male, 38% female) with mean age 12.26±4.74 years, mean pre-transfusion hemoglobin 8.64±1.01 g/dl, mean serum ferritin 1158.6±556.8 ng/ml were included. Vitamin D (72.4%), selenium (72.4%), folate (37.9%) deficiencies were the most frequent ones. In 17.2% hypocalcemia, 3.5% hypomagnesemia, in 10.3 % decreased ceruloplasmin were observed. Folate was higher between 2≤ and<6 years (p:0.028). Ceruloplasmin was higher between 6≤ and<10 years (p:0.018). Selenium was significantly higher in patients with ferritin ≥1500 (p=0.008). No significant ferritin-related differences were found in other micronutrients (p>0.05)For body mass index (BMI) 31% were under the 5th percentile, none was over the 95th percentile. For height, 24.5%, for weight 20.7% were under the 3rd, none was over 97th percentile. BMI of patients 10≤age≤18 years old was significantly higher (p=0.001). Anthropometric percentiles did not differ significantly in terms of mean serum ferritin and micronutrient levels. Hypoparathyroidism was observed in 13.8%, hypothyroidism in 3.5% of the patients. Low bone density was detected in 14.8% (2 osteopenic, 2 osteoporotic) patients. Bone mineral density did not differ significantly in terms of ferritin and micronutrient levels. Conclusions: Nutritional support and prevention of deficiencies are important to minimize the burden of complications, to increase the life expectancy and quality in TM patients.
format	article
author	Serap Cevher Bulğurcu Aylin Canbolat Ayhan Hamdi Emeksiz Fahri Ovalı
author_facet	Serap Cevher Bulğurcu Aylin Canbolat Ayhan Hamdi Emeksiz Fahri Ovalı
author_sort	Serap Cevher Bulğurcu
title	ASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR
title_short	ASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR
title_full	ASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR
title_fullStr	ASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR
title_full_unstemmed	ASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR
title_sort	assessment of the nutritional status, bone mineralization and anthropometrics of children with thalassemia major
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f8f193168b6e4e2ca35eb74974b224c4
work_keys_str_mv	AT serapcevherbulgurcu assessmentofthenutritionalstatusbonemineralizationandanthropometricsofchildrenwiththalassemiamajor AT aylincanbolatayhan assessmentofthenutritionalstatusbonemineralizationandanthropometricsofchildrenwiththalassemiamajor AT hamdiemeksiz assessmentofthenutritionalstatusbonemineralizationandanthropometricsofchildrenwiththalassemiamajor AT fahriovalı assessmentofthenutritionalstatusbonemineralizationandanthropometricsofchildrenwiththalassemiamajor
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ASSESSMENT OF THE NUTRITIONAL STATUS, BONE MINERALIZATION AND ANTHROPOMETRICS OF CHILDREN WITH THALASSEMIA MAJOR

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