Joint effects of genes underlying a temperature specialization tradeoff in yeast.

A central goal of evolutionary genetics is to understand, at the molecular level, how organisms adapt to their environments. For a given trait, the answer often involves the acquisition of variants at unlinked sites across the genome. Genomic methods have achieved landmark successes in pinpointing t...

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Autores principales:	Faisal AlZaben, Julie N Chuong, Melanie B Abrams, Rachel B Brem
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/f8f20cead1e54609be12ae28760284e3
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spelling	oai:doaj.org-article:f8f20cead1e54609be12ae28760284e32021-12-02T20:03:19ZJoint effects of genes underlying a temperature specialization tradeoff in yeast.1553-73901553-740410.1371/journal.pgen.1009793https://doaj.org/article/f8f20cead1e54609be12ae28760284e32021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009793https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404A central goal of evolutionary genetics is to understand, at the molecular level, how organisms adapt to their environments. For a given trait, the answer often involves the acquisition of variants at unlinked sites across the genome. Genomic methods have achieved landmark successes in pinpointing these adaptive loci. To figure out how a suite of adaptive alleles work together, and to what extent they can reconstitute the phenotype of interest, requires their transfer into an exogenous background. We studied the joint effect of adaptive, gain-of-function thermotolerance alleles at eight unlinked genes from Saccharomyces cerevisiae, when introduced into a thermosensitive sister species, S. paradoxus. Although the loci damped each other's beneficial impact (that is, they were subject to negative epistasis), most boosted high-temperature growth alone and in combination, and none was deleterious. The complete set of eight genes was sufficient to confer ~15% of the S. cerevisiae thermotolerance phenotype in the S. paradoxus background. The same loci also contributed to a heretofore unknown advantage in cold growth by S. paradoxus. Together, our data establish temperature resistance in yeasts as a model case of a genetically complex evolutionary tradeoff, which can be partly reconstituted from the sequential assembly of unlinked underlying loci.Faisal AlZabenJulie N ChuongMelanie B AbramsRachel B BremPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 9, p e1009793 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Faisal AlZaben Julie N Chuong Melanie B Abrams Rachel B Brem Joint effects of genes underlying a temperature specialization tradeoff in yeast.
description	A central goal of evolutionary genetics is to understand, at the molecular level, how organisms adapt to their environments. For a given trait, the answer often involves the acquisition of variants at unlinked sites across the genome. Genomic methods have achieved landmark successes in pinpointing these adaptive loci. To figure out how a suite of adaptive alleles work together, and to what extent they can reconstitute the phenotype of interest, requires their transfer into an exogenous background. We studied the joint effect of adaptive, gain-of-function thermotolerance alleles at eight unlinked genes from Saccharomyces cerevisiae, when introduced into a thermosensitive sister species, S. paradoxus. Although the loci damped each other's beneficial impact (that is, they were subject to negative epistasis), most boosted high-temperature growth alone and in combination, and none was deleterious. The complete set of eight genes was sufficient to confer ~15% of the S. cerevisiae thermotolerance phenotype in the S. paradoxus background. The same loci also contributed to a heretofore unknown advantage in cold growth by S. paradoxus. Together, our data establish temperature resistance in yeasts as a model case of a genetically complex evolutionary tradeoff, which can be partly reconstituted from the sequential assembly of unlinked underlying loci.
format	article
author	Faisal AlZaben Julie N Chuong Melanie B Abrams Rachel B Brem
author_facet	Faisal AlZaben Julie N Chuong Melanie B Abrams Rachel B Brem
author_sort	Faisal AlZaben
title	Joint effects of genes underlying a temperature specialization tradeoff in yeast.
title_short	Joint effects of genes underlying a temperature specialization tradeoff in yeast.
title_full	Joint effects of genes underlying a temperature specialization tradeoff in yeast.
title_fullStr	Joint effects of genes underlying a temperature specialization tradeoff in yeast.
title_full_unstemmed	Joint effects of genes underlying a temperature specialization tradeoff in yeast.
title_sort	joint effects of genes underlying a temperature specialization tradeoff in yeast.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f8f20cead1e54609be12ae28760284e3
work_keys_str_mv	AT faisalalzaben jointeffectsofgenesunderlyingatemperaturespecializationtradeoffinyeast AT julienchuong jointeffectsofgenesunderlyingatemperaturespecializationtradeoffinyeast AT melaniebabrams jointeffectsofgenesunderlyingatemperaturespecializationtradeoffinyeast AT rachelbbrem jointeffectsofgenesunderlyingatemperaturespecializationtradeoffinyeast
_version_	1718375698531352576

Joint effects of genes underlying a temperature specialization tradeoff in yeast.

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