Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood

Abstract Alcohol and nicotine are the two most commonly-abused substances and are often used together. Nicotine enhances alcohol-drinking behaviors in humans and in animals, and was suggested to enhance the reinforcing properties of other reinforcers. Here, we show that nicotine-associated environme...

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Autores principales:	Dor Zipori, Yossi Sadot-Sogrin, Koral Goltseker, Oren Even-Chen, Nofar Rahamim, Ohad Shaham, Segev Barak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8f2185bf957410baf9834927dd33e21
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spelling	oai:doaj.org-article:f8f2185bf957410baf9834927dd33e212021-12-02T15:06:25ZRe-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood10.1038/s41598-017-02177-22045-2322https://doaj.org/article/f8f2185bf957410baf9834927dd33e212017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02177-2https://doaj.org/toc/2045-2322Abstract Alcohol and nicotine are the two most commonly-abused substances and are often used together. Nicotine enhances alcohol-drinking behaviors in humans and in animals, and was suggested to enhance the reinforcing properties of other reinforcers. Here, we show that nicotine-associated environment, rather than nicotine itself, enhances alcohol intake in rats. Adolescent rats received repeated intermittent injections of nicotine (0.4 mg/kg, i.p., 5 injections, every 3rd day) or saline. The injection was paired with their home cage, or with the subsequent alcohol self-administration context. Rats were then trained to self-administer 20% alcohol. Nicotine given in the home cage did not alter subsequent alcohol intake. However, pairing nicotine with the operant chamber during adolescence led to a long-lasting increased alcohol self-administration in adulthood, compared to nicotine pre-treatment in other contexts. This effect persisted 3 months after nicotine cessation, in a relapse test after abstinence. Furthermore, re-exposure to the nicotine-associated context in adult rats led to a decrease in glial cell line-derived neurotrophic factor (Gdnf) mRNA expression in the ventral tegmental area, an effect that leads to increased alcohol consumption, as we have previously reported. Our findings suggest that retrieval of nicotine-associated contextual memories from adolescence may gate alcohol intake in adulthood, with a possible involvement of GDNF.Dor ZiporiYossi Sadot-SogrinKoral GoltsekerOren Even-ChenNofar RahamimOhad ShahamSegev BarakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dor Zipori Yossi Sadot-Sogrin Koral Goltseker Oren Even-Chen Nofar Rahamim Ohad Shaham Segev Barak Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood
description	Abstract Alcohol and nicotine are the two most commonly-abused substances and are often used together. Nicotine enhances alcohol-drinking behaviors in humans and in animals, and was suggested to enhance the reinforcing properties of other reinforcers. Here, we show that nicotine-associated environment, rather than nicotine itself, enhances alcohol intake in rats. Adolescent rats received repeated intermittent injections of nicotine (0.4 mg/kg, i.p., 5 injections, every 3rd day) or saline. The injection was paired with their home cage, or with the subsequent alcohol self-administration context. Rats were then trained to self-administer 20% alcohol. Nicotine given in the home cage did not alter subsequent alcohol intake. However, pairing nicotine with the operant chamber during adolescence led to a long-lasting increased alcohol self-administration in adulthood, compared to nicotine pre-treatment in other contexts. This effect persisted 3 months after nicotine cessation, in a relapse test after abstinence. Furthermore, re-exposure to the nicotine-associated context in adult rats led to a decrease in glial cell line-derived neurotrophic factor (Gdnf) mRNA expression in the ventral tegmental area, an effect that leads to increased alcohol consumption, as we have previously reported. Our findings suggest that retrieval of nicotine-associated contextual memories from adolescence may gate alcohol intake in adulthood, with a possible involvement of GDNF.
format	article
author	Dor Zipori Yossi Sadot-Sogrin Koral Goltseker Oren Even-Chen Nofar Rahamim Ohad Shaham Segev Barak
author_facet	Dor Zipori Yossi Sadot-Sogrin Koral Goltseker Oren Even-Chen Nofar Rahamim Ohad Shaham Segev Barak
author_sort	Dor Zipori
title	Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood
title_short	Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood
title_full	Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood
title_fullStr	Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood
title_full_unstemmed	Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood
title_sort	re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f8f2185bf957410baf9834927dd33e21
work_keys_str_mv	AT dorzipori reexposuretonicotineassociatedcontextfromadolescenceenhancesalcoholintakeinadulthood AT yossisadotsogrin reexposuretonicotineassociatedcontextfromadolescenceenhancesalcoholintakeinadulthood AT koralgoltseker reexposuretonicotineassociatedcontextfromadolescenceenhancesalcoholintakeinadulthood AT orenevenchen reexposuretonicotineassociatedcontextfromadolescenceenhancesalcoholintakeinadulthood AT nofarrahamim reexposuretonicotineassociatedcontextfromadolescenceenhancesalcoholintakeinadulthood AT ohadshaham reexposuretonicotineassociatedcontextfromadolescenceenhancesalcoholintakeinadulthood AT segevbarak reexposuretonicotineassociatedcontextfromadolescenceenhancesalcoholintakeinadulthood
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Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood

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