Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?

The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and possesses unique characteristics that make the delivery of drugs to the brain a great challenge. To achieve this purpose, it is necessary to design strategies to allow BBB passage, in order to reach the bra...

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Autores principales:	Rúben G. R. Pinheiro, Ana Joyce Coutinho, Marina Pinheiro, Ana Rute Neves
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease drug delivery drug targeting neurodegenerative diseases Parkinson’s disease Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f8f503332d9e40ada4177774d6bea6d7
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spelling	oai:doaj.org-article:f8f503332d9e40ada4177774d6bea6d72021-11-11T17:07:23ZNanoparticles for Targeted Brain Drug Delivery: What Do We Know?10.3390/ijms2221116541422-00671661-6596https://doaj.org/article/f8f503332d9e40ada4177774d6bea6d72021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11654https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and possesses unique characteristics that make the delivery of drugs to the brain a great challenge. To achieve this purpose, it is necessary to design strategies to allow BBB passage, in order to reach the brain and target the desired anatomic region. The use of nanomedicine has great potential to overcome this problem, since one can modify nanoparticles with strategic molecules that can interact with the BBB and induce uptake through the brain endothelial cells and consequently reach the brain tissue. This review addresses the potential of nanomedicines to treat neurological diseases by using nanoparticles specially developed to cross the BBB.Rúben G. R. PinheiroAna Joyce CoutinhoMarina PinheiroAna Rute NevesMDPI AGarticleAlzheimer’s diseasedrug deliverydrug targetingneurodegenerative diseasesParkinson’s diseaseBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11654, p 11654 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease drug delivery drug targeting neurodegenerative diseases Parkinson’s disease Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Alzheimer’s disease drug delivery drug targeting neurodegenerative diseases Parkinson’s disease Biology (General) QH301-705.5 Chemistry QD1-999 Rúben G. R. Pinheiro Ana Joyce Coutinho Marina Pinheiro Ana Rute Neves Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?
description	The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and possesses unique characteristics that make the delivery of drugs to the brain a great challenge. To achieve this purpose, it is necessary to design strategies to allow BBB passage, in order to reach the brain and target the desired anatomic region. The use of nanomedicine has great potential to overcome this problem, since one can modify nanoparticles with strategic molecules that can interact with the BBB and induce uptake through the brain endothelial cells and consequently reach the brain tissue. This review addresses the potential of nanomedicines to treat neurological diseases by using nanoparticles specially developed to cross the BBB.
format	article
author	Rúben G. R. Pinheiro Ana Joyce Coutinho Marina Pinheiro Ana Rute Neves
author_facet	Rúben G. R. Pinheiro Ana Joyce Coutinho Marina Pinheiro Ana Rute Neves
author_sort	Rúben G. R. Pinheiro
title	Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?
title_short	Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?
title_full	Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?
title_fullStr	Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?
title_full_unstemmed	Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?
title_sort	nanoparticles for targeted brain drug delivery: what do we know?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f8f503332d9e40ada4177774d6bea6d7
work_keys_str_mv	AT rubengrpinheiro nanoparticlesfortargetedbraindrugdeliverywhatdoweknow AT anajoycecoutinho nanoparticlesfortargetedbraindrugdeliverywhatdoweknow AT marinapinheiro nanoparticlesfortargetedbraindrugdeliverywhatdoweknow AT anaruteneves nanoparticlesfortargetedbraindrugdeliverywhatdoweknow
_version_	1718432216520851456

Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?

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