Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

Cells must be robust to the mechanical demands of their environments. Here, Gilbert et al. expose cells to high-intensity strain cycling and use proteomics to identify a protein, SUN2, that behaves as a strain-induced breakpoint that can decouple the nucleoskeleton from the cytoskeleton.

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Autores principales:	Hamish T. J. Gilbert, Venkatesh Mallikarjun, Oana Dobre, Mark R. Jackson, Robert Pedley, Andrew P. Gilmore, Stephen M. Richardson, Joe Swift
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8f759b44d8640cea035f511934e57db
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spelling	oai:doaj.org-article:f8f759b44d8640cea035f511934e57db2021-12-02T15:35:05ZNuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading10.1038/s41467-019-11923-12041-1723https://doaj.org/article/f8f759b44d8640cea035f511934e57db2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11923-1https://doaj.org/toc/2041-1723Cells must be robust to the mechanical demands of their environments. Here, Gilbert et al. expose cells to high-intensity strain cycling and use proteomics to identify a protein, SUN2, that behaves as a strain-induced breakpoint that can decouple the nucleoskeleton from the cytoskeleton.Hamish T. J. GilbertVenkatesh MallikarjunOana DobreMark R. JacksonRobert PedleyAndrew P. GilmoreStephen M. RichardsonJoe SwiftNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hamish T. J. Gilbert Venkatesh Mallikarjun Oana Dobre Mark R. Jackson Robert Pedley Andrew P. Gilmore Stephen M. Richardson Joe Swift Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading
description	Cells must be robust to the mechanical demands of their environments. Here, Gilbert et al. expose cells to high-intensity strain cycling and use proteomics to identify a protein, SUN2, that behaves as a strain-induced breakpoint that can decouple the nucleoskeleton from the cytoskeleton.
format	article
author	Hamish T. J. Gilbert Venkatesh Mallikarjun Oana Dobre Mark R. Jackson Robert Pedley Andrew P. Gilmore Stephen M. Richardson Joe Swift
author_facet	Hamish T. J. Gilbert Venkatesh Mallikarjun Oana Dobre Mark R. Jackson Robert Pedley Andrew P. Gilmore Stephen M. Richardson Joe Swift
author_sort	Hamish T. J. Gilbert
title	Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading
title_short	Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading
title_full	Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading
title_fullStr	Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading
title_full_unstemmed	Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading
title_sort	nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f8f759b44d8640cea035f511934e57db
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Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

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