PATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM

Decreased production of blocking factors (BF) is a common manifestation of immune dysfunction in women with recurrent spontaneous abortions (RSA), and this disorder may be corrected by lymphocyte immunotherapy performed with paternal lymphocytes (LIT). Our previously data show, in a half of RSA case...

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Autores principales:	N. A. Khonina, E. A. Ladigina, A. N. Vyatchinina, N. M. Pasman, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	blocking factor recurrent spontaneous abortion infertility of unknown origin lymphocyte immunotherapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f8fb7a8e4ab7469488d6440133a03bb3
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spelling	oai:doaj.org-article:f8fb7a8e4ab7469488d6440133a03bb32021-11-18T08:03:37ZPATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM1563-06252313-741X10.15789/1563-0625-2014-1-61-70https://doaj.org/article/f8fb7a8e4ab7469488d6440133a03bb32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/25https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDecreased production of blocking factors (BF) is a common manifestation of immune dysfunction in women with recurrent spontaneous abortions (RSA), and this disorder may be corrected by lymphocyte immunotherapy performed with paternal lymphocytes (LIT). Our previously data show, in a half of RSA cases, BF deficiency is not associated with a reduced MLC response, being detected not only in RSA, but also in primary infertility of unknown origin. In this work we have investigated the effect of LIT upon BF activity and evaluated clinical efficacy of immunotherapy in women with RSA and primary unexplained infertility, taking into account the efficiency of BF production. The lymphocytes immunotherapy was accompanied by the appearance of BF in women with RSA (75%) and in women with primary unexplained infertility (74%). BF were detected at similar frequency in the groups of women with intact and reduced response in MLC. Clinical efficacy (number of births) was – 65.5% in RSA group, and 40% in primary infertility. The rate of successful pregnancy in both groups was shown to be significantly higher in women positive for BF as compared with the BF-negative women, including women with RSA (70% vs 28%) and primary infertility (50 vs 9%). Hence, LIT in BF-negative women is accompanied by enhanced production of blocking factors, thus being associated with improved pregnancy outcomes, both in females with history of RSA, and in women with unexplained infertilityN. A. KhoninaE. A. LadiginaA. N. VyatchininaN. M. PasmanE. R. ChernykhSPb RAACIarticleblocking factorrecurrent spontaneous abortioninfertility of unknown originlymphocyte immunotherapyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 1, Pp 61-70 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	blocking factor recurrent spontaneous abortion infertility of unknown origin lymphocyte immunotherapy Immunologic diseases. Allergy RC581-607
spellingShingle	blocking factor recurrent spontaneous abortion infertility of unknown origin lymphocyte immunotherapy Immunologic diseases. Allergy RC581-607 N. A. Khonina E. A. Ladigina A. N. Vyatchinina N. M. Pasman E. R. Chernykh PATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM
description	Decreased production of blocking factors (BF) is a common manifestation of immune dysfunction in women with recurrent spontaneous abortions (RSA), and this disorder may be corrected by lymphocyte immunotherapy performed with paternal lymphocytes (LIT). Our previously data show, in a half of RSA cases, BF deficiency is not associated with a reduced MLC response, being detected not only in RSA, but also in primary infertility of unknown origin. In this work we have investigated the effect of LIT upon BF activity and evaluated clinical efficacy of immunotherapy in women with RSA and primary unexplained infertility, taking into account the efficiency of BF production. The lymphocytes immunotherapy was accompanied by the appearance of BF in women with RSA (75%) and in women with primary unexplained infertility (74%). BF were detected at similar frequency in the groups of women with intact and reduced response in MLC. Clinical efficacy (number of births) was – 65.5% in RSA group, and 40% in primary infertility. The rate of successful pregnancy in both groups was shown to be significantly higher in women positive for BF as compared with the BF-negative women, including women with RSA (70% vs 28%) and primary infertility (50 vs 9%). Hence, LIT in BF-negative women is accompanied by enhanced production of blocking factors, thus being associated with improved pregnancy outcomes, both in females with history of RSA, and in women with unexplained infertility
format	article
author	N. A. Khonina E. A. Ladigina A. N. Vyatchinina N. M. Pasman E. R. Chernykh
author_facet	N. A. Khonina E. A. Ladigina A. N. Vyatchinina N. M. Pasman E. R. Chernykh
author_sort	N. A. Khonina
title	PATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM
title_short	PATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM
title_full	PATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM
title_fullStr	PATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM
title_full_unstemmed	PATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM
title_sort	paternal lymphocyte alloimmunization in the treatment of infertility: a new look at an old problem
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f8fb7a8e4ab7469488d6440133a03bb3
work_keys_str_mv	AT nakhonina paternallymphocytealloimmunizationinthetreatmentofinfertilityanewlookatanoldproblem AT ealadigina paternallymphocytealloimmunizationinthetreatmentofinfertilityanewlookatanoldproblem AT anvyatchinina paternallymphocytealloimmunizationinthetreatmentofinfertilityanewlookatanoldproblem AT nmpasman paternallymphocytealloimmunizationinthetreatmentofinfertilityanewlookatanoldproblem AT erchernykh paternallymphocytealloimmunizationinthetreatmentofinfertilityanewlookatanoldproblem
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PATERNAL LYMPHOCYTE ALLOIMMUNIZATION IN THE TREATMENT OF INFERTILITY: A NEW LOOK AT AN OLD PROBLEM

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