A novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation

Abstract Biopesticides are biological pest control agents that are viewed as safer alternatives to the synthetic chemicals that dominate the global insecticide market. A major constraint on the wider adoption of biopesticides is their susceptibility to the ultraviolet (UV: 290–400 nm) radiation in s...

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Autores principales:	Kenneth Wilson, David Grzywacz, Igor Curcic, Freya Scoates, Karen Harper, Annabel Rice, Nigel Paul, Aoife Dillon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8fc5d6b92384195907d2bc68f7ac2fd
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spelling	oai:doaj.org-article:f8fc5d6b92384195907d2bc68f7ac2fd2021-12-02T16:35:41ZA novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation10.1038/s41598-020-70293-72045-2322https://doaj.org/article/f8fc5d6b92384195907d2bc68f7ac2fd2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70293-7https://doaj.org/toc/2045-2322Abstract Biopesticides are biological pest control agents that are viewed as safer alternatives to the synthetic chemicals that dominate the global insecticide market. A major constraint on the wider adoption of biopesticides is their susceptibility to the ultraviolet (UV: 290–400 nm) radiation in sunlight, which limits their persistence and efficacy. Here, we describe a novel formulation technology for biopesticides in which the active ingredient (baculovirus) is micro-encapsulated in an ENTOSTAT wax combined with a UV absorbant (titanium dioxide, TiO2). Importantly, this capsule protects the sensitive viral DNA from degrading in sunlight, but dissolves in the alkaline insect gut to release the virus, which then infects and kills the pest. We show, using simulated sunlight, in both laboratory bioassays and trials on cabbage and tomato plants, that this can extend the efficacy of the biopesticide well beyond the few hours of existing virus formulations, potentially increasing the spray interval and/or reducing the need for high application rates. The new formulation has a shelf-life at 30 °C of at least 6 months, which is comparable to standard commercial biopesticides and has no phytotoxic effect on the host plants. Taken together, these findings suggest that the new formulation technology could reduce the costs and increase the efficacy of baculovirus biopesticides, with the potential to make them commercially competitive alternatives to synthetic chemicals.Kenneth WilsonDavid GrzywaczIgor CurcicFreya ScoatesKaren HarperAnnabel RiceNigel PaulAoife DillonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenneth Wilson David Grzywacz Igor Curcic Freya Scoates Karen Harper Annabel Rice Nigel Paul Aoife Dillon A novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation
description	Abstract Biopesticides are biological pest control agents that are viewed as safer alternatives to the synthetic chemicals that dominate the global insecticide market. A major constraint on the wider adoption of biopesticides is their susceptibility to the ultraviolet (UV: 290–400 nm) radiation in sunlight, which limits their persistence and efficacy. Here, we describe a novel formulation technology for biopesticides in which the active ingredient (baculovirus) is micro-encapsulated in an ENTOSTAT wax combined with a UV absorbant (titanium dioxide, TiO2). Importantly, this capsule protects the sensitive viral DNA from degrading in sunlight, but dissolves in the alkaline insect gut to release the virus, which then infects and kills the pest. We show, using simulated sunlight, in both laboratory bioassays and trials on cabbage and tomato plants, that this can extend the efficacy of the biopesticide well beyond the few hours of existing virus formulations, potentially increasing the spray interval and/or reducing the need for high application rates. The new formulation has a shelf-life at 30 °C of at least 6 months, which is comparable to standard commercial biopesticides and has no phytotoxic effect on the host plants. Taken together, these findings suggest that the new formulation technology could reduce the costs and increase the efficacy of baculovirus biopesticides, with the potential to make them commercially competitive alternatives to synthetic chemicals.
format	article
author	Kenneth Wilson David Grzywacz Igor Curcic Freya Scoates Karen Harper Annabel Rice Nigel Paul Aoife Dillon
author_facet	Kenneth Wilson David Grzywacz Igor Curcic Freya Scoates Karen Harper Annabel Rice Nigel Paul Aoife Dillon
author_sort	Kenneth Wilson
title	A novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation
title_short	A novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation
title_full	A novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation
title_fullStr	A novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation
title_full_unstemmed	A novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation
title_sort	novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f8fc5d6b92384195907d2bc68f7ac2fd
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A novel formulation technology for baculoviruses protects biopesticide from degradation by ultraviolet radiation

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