Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis

Marina Mitie Monobe,1 Kari V Lunsford,2 João Pessoa Araújo Jr,3 Camilo Bulla41Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, Brazil; 2Department of Clinical Sciences and Animal Health Center, College of...

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Autores principales:	Monobe MM, Lunsford KV, Ara&uacute;jo Jr JP, Bulla C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/f9007aaab80e4af8b5829286fa038ca2
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spelling	oai:doaj.org-article:f9007aaab80e4af8b5829286fa038ca22021-12-02T00:54:35ZDetection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis2230-2034https://doaj.org/article/f9007aaab80e4af8b5829286fa038ca22013-10-01T00:00:00Zhttp://www.dovepress.com/detection-of-heterozygous-mdr1-nt230del4-mutation-in-a-mixed-breed-dog-a14600https://doaj.org/toc/2230-2034Marina Mitie Monobe,1 Kari V Lunsford,2 João Pessoa Araújo Jr,3 Camilo Bulla41Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, Brazil; 2Department of Clinical Sciences and Animal Health Center, College of Veterinary Medicine, Mississippi State University, MS, USA; 3Department of Microbiology and Immunology, Biosciences Institute, Sao Paulo State University, Botucatu, Brazil; 4Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, MS, USAAbstract: P-glycoprotein (ABCB1), the product of the Multidrug Resistance Gene (MDR1) (ABCB1) gene, is the major multidrug transporter contributing to the barrier function of several tissues and organs, including the brain. A four base pair deletion mutation in MDR1 results in the absence of a functional form of ABCB1 and loss of its protective function. Severe intoxication with the ABCB1 substrate, such as with anticancer drugs, has been attributed to genetic lack of functional ABCB1. This mutation has been detected in more than 10 dog breeds as well as in mixed-breed dogs living in different countries. In Brazil, evaluation for this mutation is not as widely available and is rarely used by veterinarians, so drug intoxication may be underdiagnosed. This is the first report from Brazil of doxorubicin neurotoxicity in a mixed-breed dog with the MDR1 nt230(del4) mutation.Keywords: canine, toxicology, cancer, P-glycoproteinMonobe MMLunsford KVAra&uacute;jo Jr JPBulla CDove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2013, Iss default, Pp 35-38 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Monobe MM Lunsford KV Ara&uacute;jo Jr JP Bulla C Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis
description	Marina Mitie Monobe,1 Kari V Lunsford,2 João Pessoa Araújo Jr,3 Camilo Bulla41Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, Brazil; 2Department of Clinical Sciences and Animal Health Center, College of Veterinary Medicine, Mississippi State University, MS, USA; 3Department of Microbiology and Immunology, Biosciences Institute, Sao Paulo State University, Botucatu, Brazil; 4Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, MS, USAAbstract: P-glycoprotein (ABCB1), the product of the Multidrug Resistance Gene (MDR1) (ABCB1) gene, is the major multidrug transporter contributing to the barrier function of several tissues and organs, including the brain. A four base pair deletion mutation in MDR1 results in the absence of a functional form of ABCB1 and loss of its protective function. Severe intoxication with the ABCB1 substrate, such as with anticancer drugs, has been attributed to genetic lack of functional ABCB1. This mutation has been detected in more than 10 dog breeds as well as in mixed-breed dogs living in different countries. In Brazil, evaluation for this mutation is not as widely available and is rarely used by veterinarians, so drug intoxication may be underdiagnosed. This is the first report from Brazil of doxorubicin neurotoxicity in a mixed-breed dog with the MDR1 nt230(del4) mutation.Keywords: canine, toxicology, cancer, P-glycoprotein
format	article
author	Monobe MM Lunsford KV Ara&uacute;jo Jr JP Bulla C
author_facet	Monobe MM Lunsford KV Ara&uacute;jo Jr JP Bulla C
author_sort	Monobe MM
title	Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis
title_short	Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis
title_full	Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis
title_fullStr	Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis
title_full_unstemmed	Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis
title_sort	detection of heterozygous mdr1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f9007aaab80e4af8b5829286fa038ca2
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Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis

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