Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations
Tumour heterogeneity is well-known; however, studies analysing the progression from primary to metastatic disease are still limited. Here, the authors used phylogenetic analyses and found that for some patients there are multiple seeding events from the primary tumour accompanied by cross-seeding be...
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2017
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oai:doaj.org-article:f90827da54f540e984fa2703ff7e29bc2021-12-02T17:01:23ZPhylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations10.1038/ncomms149442041-1723https://doaj.org/article/f90827da54f540e984fa2703ff7e29bc2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14944https://doaj.org/toc/2041-1723Tumour heterogeneity is well-known; however, studies analysing the progression from primary to metastatic disease are still limited. Here, the authors used phylogenetic analyses and found that for some patients there are multiple seeding events from the primary tumour accompanied by cross-seeding between metastases.David BrownDominiek SmeetsBorbála SzékelyDenis LarsimontA. Marcell SzászPierre-Yves AdnetFrançoise RothéGhizlane RouasZsófia I. NagyZsófia FaragóAnna-Mária TőkésMagdolna DankGyöngyvér SzentmártoniNóra UdvarhelyiGabriele ZoppoliLajos PusztaiMartine PiccartJanina KulkaDiether LambrechtsChristos SotiriouChristine DesmedtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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Science Q |
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Science Q David Brown Dominiek Smeets Borbála Székely Denis Larsimont A. Marcell Szász Pierre-Yves Adnet Françoise Rothé Ghizlane Rouas Zsófia I. Nagy Zsófia Faragó Anna-Mária Tőkés Magdolna Dank Gyöngyvér Szentmártoni Nóra Udvarhelyi Gabriele Zoppoli Lajos Pusztai Martine Piccart Janina Kulka Diether Lambrechts Christos Sotiriou Christine Desmedt Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations |
| description |
Tumour heterogeneity is well-known; however, studies analysing the progression from primary to metastatic disease are still limited. Here, the authors used phylogenetic analyses and found that for some patients there are multiple seeding events from the primary tumour accompanied by cross-seeding between metastases. |
| format |
article |
| author |
David Brown Dominiek Smeets Borbála Székely Denis Larsimont A. Marcell Szász Pierre-Yves Adnet Françoise Rothé Ghizlane Rouas Zsófia I. Nagy Zsófia Faragó Anna-Mária Tőkés Magdolna Dank Gyöngyvér Szentmártoni Nóra Udvarhelyi Gabriele Zoppoli Lajos Pusztai Martine Piccart Janina Kulka Diether Lambrechts Christos Sotiriou Christine Desmedt |
| author_facet |
David Brown Dominiek Smeets Borbála Székely Denis Larsimont A. Marcell Szász Pierre-Yves Adnet Françoise Rothé Ghizlane Rouas Zsófia I. Nagy Zsófia Faragó Anna-Mária Tőkés Magdolna Dank Gyöngyvér Szentmártoni Nóra Udvarhelyi Gabriele Zoppoli Lajos Pusztai Martine Piccart Janina Kulka Diether Lambrechts Christos Sotiriou Christine Desmedt |
| author_sort |
David Brown |
| title |
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations |
| title_short |
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations |
| title_full |
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations |
| title_fullStr |
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations |
| title_full_unstemmed |
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations |
| title_sort |
phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/f90827da54f540e984fa2703ff7e29bc |
| work_keys_str_mv |
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| _version_ |
1718382188388417536 |