Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results

Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results

Anastasios John Kanellopoulos,1,2 George Asimellis,1 Costas Karabatsas1 1LaserVision.gr Clinical and Research Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USA Purpose: To compare 1-year results: safety, efficacy, refractive and keratometric stability, o...

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Autores principales: Kanellopoulos AJ, Asimellis G, Karabatsas C
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
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Ophthalmology
RE1-994
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spelling oai:doaj.org-article:f9088398250143c78a00dfacaf08f6bd2021-12-02T03:13:51ZComparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results1177-5483https://doaj.org/article/f9088398250143c78a00dfacaf08f6bd2014-11-01T00:00:00Zhttp://www.dovepress.com/comparison-of-prophylactic-higher-fluence-corneal-cross-linking-to-con-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Anastasios John Kanellopoulos,1,2 George Asimellis,1 Costas Karabatsas1 1LaserVision.gr Clinical and Research Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USA Purpose: To compare 1-year results: safety, efficacy, refractive and keratometric stability, of femtosecond myopic laser-assisted in situ keratomileusis (LASIK) with and without concurrent prophylactic high-fluence cross-linking (CXL) (LASIK-CXL).Methods: We studied a total of 155 consecutive eyes planned for LASIK myopic correction. Group A represented 73 eyes that were treated additionally with concurrent prophylactic high-fluence CXL; group B included 82 eyes subjected to the stand-alone LASIK procedure. The following parameters were evaluated preoperatively and up to 1-year postoperatively: manifest refractive spherical equivalent (MRSE), refractive astigmatism, visual acuity, corneal keratometry, and endothelial cell counts. We plotted keratometry measurements pre-operatively and its change in the early, interim and later post-operative time for the two groups, as a means of keratometric stability comparison.Results: Group A (LASIK-CXL) had an average postoperative MRSE of -0.23, -0.19, and -0.19 D for the 3-, 6-, and 12-month period, respectively, compared to -6.58±1.98 D preoperatively. Flat keratometry was 37.69, 37.66, and 37.67 D, compared to 43.94 D preoperatively, and steep keratometry was 38.35, 38.36, and 38.37 D, compared to 45.17 D preoperatively. The predictability of Manifest Refraction Spherical Equivalent (MRSE) correction showed a correlation coefficient of 0.979. Group B (stand-alone LASIK) had an average postoperative MRSE of -0.23, -0.20, and -0.27 D for the 3-, 6-, and 12-month period, respectively, compared with -5.14±2.34 D preoperatively. Flat keratometry was 37.65, 37.89, and 38.02 D, compared with 43.15 D preoperatively, and steep keratometry was 38.32, 38.57, and 38.66 D, compared with 44.07 D preoperatively. The predictability of MRSE correction showed a correlation coefficient of 0.970. The keratometric stability plots were stable for the LASIK CXL group and slightly regressing in the standard LASIK group, a novel stability evaluation metric that may escape routine acuity and refraction measurements.Conclusion: Application of prophylactic CXL concurrently with myopic LASIK surgery appears to contribute to improved refractive and keratometric stability compared to standard LASIK. The procedure appears safe and provides a new potential for LASIK correction. Keywords: myopic LASIK regression, femtosecond myopic LASIK, LASIK-CXL, LASIK-Xtra, high myopia, accelerated high-fluence collagen cross-linkingKanellopoulos AJAsimellis GKarabatsas CDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2373-2381 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Kanellopoulos AJ
Asimellis G
Karabatsas C
Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results
description Anastasios John Kanellopoulos,1,2 George Asimellis,1 Costas Karabatsas1 1LaserVision.gr Clinical and Research Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USA Purpose: To compare 1-year results: safety, efficacy, refractive and keratometric stability, of femtosecond myopic laser-assisted in situ keratomileusis (LASIK) with and without concurrent prophylactic high-fluence cross-linking (CXL) (LASIK-CXL).Methods: We studied a total of 155 consecutive eyes planned for LASIK myopic correction. Group A represented 73 eyes that were treated additionally with concurrent prophylactic high-fluence CXL; group B included 82 eyes subjected to the stand-alone LASIK procedure. The following parameters were evaluated preoperatively and up to 1-year postoperatively: manifest refractive spherical equivalent (MRSE), refractive astigmatism, visual acuity, corneal keratometry, and endothelial cell counts. We plotted keratometry measurements pre-operatively and its change in the early, interim and later post-operative time for the two groups, as a means of keratometric stability comparison.Results: Group A (LASIK-CXL) had an average postoperative MRSE of -0.23, -0.19, and -0.19 D for the 3-, 6-, and 12-month period, respectively, compared to -6.58±1.98 D preoperatively. Flat keratometry was 37.69, 37.66, and 37.67 D, compared to 43.94 D preoperatively, and steep keratometry was 38.35, 38.36, and 38.37 D, compared to 45.17 D preoperatively. The predictability of Manifest Refraction Spherical Equivalent (MRSE) correction showed a correlation coefficient of 0.979. Group B (stand-alone LASIK) had an average postoperative MRSE of -0.23, -0.20, and -0.27 D for the 3-, 6-, and 12-month period, respectively, compared with -5.14±2.34 D preoperatively. Flat keratometry was 37.65, 37.89, and 38.02 D, compared with 43.15 D preoperatively, and steep keratometry was 38.32, 38.57, and 38.66 D, compared with 44.07 D preoperatively. The predictability of MRSE correction showed a correlation coefficient of 0.970. The keratometric stability plots were stable for the LASIK CXL group and slightly regressing in the standard LASIK group, a novel stability evaluation metric that may escape routine acuity and refraction measurements.Conclusion: Application of prophylactic CXL concurrently with myopic LASIK surgery appears to contribute to improved refractive and keratometric stability compared to standard LASIK. The procedure appears safe and provides a new potential for LASIK correction. Keywords: myopic LASIK regression, femtosecond myopic LASIK, LASIK-CXL, LASIK-Xtra, high myopia, accelerated high-fluence collagen cross-linking
format article
author Kanellopoulos AJ
Asimellis G
Karabatsas C
author_facet Kanellopoulos AJ
Asimellis G
Karabatsas C
author_sort Kanellopoulos AJ
title Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results
title_short Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results
title_full Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results
title_fullStr Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results
title_full_unstemmed Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results
title_sort comparison of prophylactic higher fluence corneal cross-linking to control, in myopic lasik, one year results
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/f9088398250143c78a00dfacaf08f6bd
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AT asimellisg comparisonofprophylactichigherfluencecornealcrosslinkingtocontrolinmyopiclasiknbsponeyearresults
AT karabatsasc comparisonofprophylactichigherfluencecornealcrosslinkingtocontrolinmyopiclasiknbsponeyearresults
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