A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML
Pediatric AML is traditionally treated with chemotherapy and stem cell transplant but some subsets of patients have a poor response to therapy. Here, the authors perform a high throughput screen and identify several FDA approved drugs that might be useful in treating this disease.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f909cbdab341455d9f702b6081a46e6f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f909cbdab341455d9f702b6081a46e6f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f909cbdab341455d9f702b6081a46e6f2021-12-02T16:58:17ZA high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML10.1038/s41467-019-09917-02041-1723https://doaj.org/article/f909cbdab341455d9f702b6081a46e6f2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09917-0https://doaj.org/toc/2041-1723Pediatric AML is traditionally treated with chemotherapy and stem cell transplant but some subsets of patients have a poor response to therapy. Here, the authors perform a high throughput screen and identify several FDA approved drugs that might be useful in treating this disease.Christina D. DrenbergAnang ShelatJinjun DangAnitria CottonShelley J. OrwickMengyu LiJae Yoon JeonQiang FuDaelynn R. BuelowMarissa PiosoShuiying HuHiroto InabaRaul C. RibeiroJeffrey E. RubnitzTanja A. GruberR. Kiplin GuySharyn D. BakerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Christina D. Drenberg Anang Shelat Jinjun Dang Anitria Cotton Shelley J. Orwick Mengyu Li Jae Yoon Jeon Qiang Fu Daelynn R. Buelow Marissa Pioso Shuiying Hu Hiroto Inaba Raul C. Ribeiro Jeffrey E. Rubnitz Tanja A. Gruber R. Kiplin Guy Sharyn D. Baker A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML |
| description |
Pediatric AML is traditionally treated with chemotherapy and stem cell transplant but some subsets of patients have a poor response to therapy. Here, the authors perform a high throughput screen and identify several FDA approved drugs that might be useful in treating this disease. |
| format |
article |
| author |
Christina D. Drenberg Anang Shelat Jinjun Dang Anitria Cotton Shelley J. Orwick Mengyu Li Jae Yoon Jeon Qiang Fu Daelynn R. Buelow Marissa Pioso Shuiying Hu Hiroto Inaba Raul C. Ribeiro Jeffrey E. Rubnitz Tanja A. Gruber R. Kiplin Guy Sharyn D. Baker |
| author_facet |
Christina D. Drenberg Anang Shelat Jinjun Dang Anitria Cotton Shelley J. Orwick Mengyu Li Jae Yoon Jeon Qiang Fu Daelynn R. Buelow Marissa Pioso Shuiying Hu Hiroto Inaba Raul C. Ribeiro Jeffrey E. Rubnitz Tanja A. Gruber R. Kiplin Guy Sharyn D. Baker |
| author_sort |
Christina D. Drenberg |
| title |
A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML |
| title_short |
A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML |
| title_full |
A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML |
| title_fullStr |
A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML |
| title_full_unstemmed |
A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML |
| title_sort |
high-throughput screen indicates gemcitabine and jak inhibitors may be useful for treating pediatric aml |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/f909cbdab341455d9f702b6081a46e6f |
| work_keys_str_mv |
AT christinaddrenberg ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT anangshelat ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT jinjundang ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT anitriacotton ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT shelleyjorwick ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT mengyuli ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT jaeyoonjeon ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT qiangfu ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT daelynnrbuelow ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT marissapioso ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT shuiyinghu ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT hirotoinaba ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT raulcribeiro ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT jeffreyerubnitz ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT tanjaagruber ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT rkiplinguy ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT sharyndbaker ahighthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT christinaddrenberg highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT anangshelat highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT jinjundang highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT anitriacotton highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT shelleyjorwick highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT mengyuli highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT jaeyoonjeon highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT qiangfu highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT daelynnrbuelow highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT marissapioso highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT shuiyinghu highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT hirotoinaba highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT raulcribeiro highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT jeffreyerubnitz highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT tanjaagruber highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT rkiplinguy highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml AT sharyndbaker highthroughputscreenindicatesgemcitabineandjakinhibitorsmaybeusefulfortreatingpediatricaml |
| _version_ |
1718382366193352704 |