Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study

Abstract Background Previous studies have revealed obesity, nutrition, lifestyle, genetic and epigenetic factors may be risk factors for the occurrence and development of non-alcoholic fatty liver disease (NAFLD). However, the effect of total polyunsaturated fatty acid (PUFA) consumption on the risk...

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Autores principales:	Yong Xie, Huan Tian, Bin Xiang, Ding Li, Jian Liu, Zhuoyan Cai, Yuzhou Liu, Hua Xiang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Non-alcoholic fatty liver disease Polyunsaturated fatty acid Case–control study Secondary analysis Risk Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/f909d81cc8e44b659e3fed44d3b8d21f
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spelling	oai:doaj.org-article:f909d81cc8e44b659e3fed44d3b8d21f2021-12-05T12:10:59ZTotal polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study10.1186/s12876-021-02039-21471-230Xhttps://doaj.org/article/f909d81cc8e44b659e3fed44d3b8d21f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02039-2https://doaj.org/toc/1471-230XAbstract Background Previous studies have revealed obesity, nutrition, lifestyle, genetic and epigenetic factors may be risk factors for the occurrence and development of non-alcoholic fatty liver disease (NAFLD). However, the effect of total polyunsaturated fatty acid (PUFA) consumption on the risk of NAFLD is uncertain. Therefore, this study aimed to determine whether the total PUFA intake is independently associated with the risk of NAFLD and explore the threshold of PUFA intake better illustrate the correlation between them in Chinese Han adults. Methods The present study was a retrospective case–control study. A total of 534 NAFLD patients and 534 controls matched by gender and age in the same center were included in this study. Using a semi-quantitative food frequency questionnaire in a health examination center in China to collect information about dietary intake and calculate nutrient consumption. A multivariate logistic regression model was used to estimate the association between total PUFA daily intake and its quartile and the incidence of NAFLD. Results Multivariate analyses suggested a significant association between total PUFA intake and the occurrence of NAFLD. A non-linear relationship between total PUFA consumption and NAFLD risk was detected after adjusting for potential confounding factors. There was a significant connection between PUFA and the risk of NAFLD (OR: 1.32, 95% CI: 1.23–1.41, P < 0.0001) when PUFA intake is between 18.8 and 29.3 g/day. Conclusions The relationship between total PUFA intake and NAFLD is non-linear. Total PUFA was positively related to the risk of NAFLD when PUFA intake is between 18.8 and 29.3 g/day among Chinese Han adults.Yong XieHuan TianBin XiangDing LiJian LiuZhuoyan CaiYuzhou LiuHua XiangBMCarticleNon-alcoholic fatty liver diseasePolyunsaturated fatty acidCase–control studySecondary analysisRiskDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Non-alcoholic fatty liver disease Polyunsaturated fatty acid Case–control study Secondary analysis Risk Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Non-alcoholic fatty liver disease Polyunsaturated fatty acid Case–control study Secondary analysis Risk Diseases of the digestive system. Gastroenterology RC799-869 Yong Xie Huan Tian Bin Xiang Ding Li Jian Liu Zhuoyan Cai Yuzhou Liu Hua Xiang Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study
description	Abstract Background Previous studies have revealed obesity, nutrition, lifestyle, genetic and epigenetic factors may be risk factors for the occurrence and development of non-alcoholic fatty liver disease (NAFLD). However, the effect of total polyunsaturated fatty acid (PUFA) consumption on the risk of NAFLD is uncertain. Therefore, this study aimed to determine whether the total PUFA intake is independently associated with the risk of NAFLD and explore the threshold of PUFA intake better illustrate the correlation between them in Chinese Han adults. Methods The present study was a retrospective case–control study. A total of 534 NAFLD patients and 534 controls matched by gender and age in the same center were included in this study. Using a semi-quantitative food frequency questionnaire in a health examination center in China to collect information about dietary intake and calculate nutrient consumption. A multivariate logistic regression model was used to estimate the association between total PUFA daily intake and its quartile and the incidence of NAFLD. Results Multivariate analyses suggested a significant association between total PUFA intake and the occurrence of NAFLD. A non-linear relationship between total PUFA consumption and NAFLD risk was detected after adjusting for potential confounding factors. There was a significant connection between PUFA and the risk of NAFLD (OR: 1.32, 95% CI: 1.23–1.41, P < 0.0001) when PUFA intake is between 18.8 and 29.3 g/day. Conclusions The relationship between total PUFA intake and NAFLD is non-linear. Total PUFA was positively related to the risk of NAFLD when PUFA intake is between 18.8 and 29.3 g/day among Chinese Han adults.
format	article
author	Yong Xie Huan Tian Bin Xiang Ding Li Jian Liu Zhuoyan Cai Yuzhou Liu Hua Xiang
author_facet	Yong Xie Huan Tian Bin Xiang Ding Li Jian Liu Zhuoyan Cai Yuzhou Liu Hua Xiang
author_sort	Yong Xie
title	Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study
title_short	Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study
title_full	Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study
title_fullStr	Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study
title_full_unstemmed	Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study
title_sort	total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in chinese han adults: a secondary analysis based on a case–control study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f909d81cc8e44b659e3fed44d3b8d21f
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Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case–control study

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