Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models

Traditional cell lines and xenograft models have been widely recognized and used in research. As a new research model, organoids have made significant progress and development in the past 10 years. Compared with traditional models, organoids have more advantages and have been applied in cancer resea...

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Auteurs principaux:	Yisheng Huang, Zhijie Huang, Zhengming Tang, Yuanxin Chen, Mingshu Huang, Hongyu Liu, Weibo Huang, Qingsong Ye, Bo Jia
Format:	article
Langue:	EN
Publié:	Frontiers Media S.A. 2021
Sujets:	organoids disease model vascularization immune environment extracellular matrix Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/f913016dfc5a486fba90ffd24e01810c
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spelling	oai:doaj.org-article:f913016dfc5a486fba90ffd24e01810c2021-11-16T05:56:02ZResearch Progress, Challenges, and Breakthroughs of Organoids as Disease Models2296-634X10.3389/fcell.2021.740574https://doaj.org/article/f913016dfc5a486fba90ffd24e01810c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.740574/fullhttps://doaj.org/toc/2296-634XTraditional cell lines and xenograft models have been widely recognized and used in research. As a new research model, organoids have made significant progress and development in the past 10 years. Compared with traditional models, organoids have more advantages and have been applied in cancer research, genetic diseases, infectious diseases, and regenerative medicine. This review presented the advantages and disadvantages of organoids in physiological development, pathological mechanism, drug screening, and organ transplantation. Further, this review summarized the current situation of vascularization, immune microenvironment, and hydrogel, which are the main influencing factors of organoids, and pointed out the future directions of development.Yisheng HuangZhijie HuangZhengming TangYuanxin ChenMingshu HuangHongyu LiuWeibo HuangQingsong YeQingsong YeBo JiaFrontiers Media S.A.articleorganoidsdisease modelvascularizationimmune environmentextracellular matrixBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	organoids disease model vascularization immune environment extracellular matrix Biology (General) QH301-705.5
spellingShingle	organoids disease model vascularization immune environment extracellular matrix Biology (General) QH301-705.5 Yisheng Huang Zhijie Huang Zhengming Tang Yuanxin Chen Mingshu Huang Hongyu Liu Weibo Huang Qingsong Ye Qingsong Ye Bo Jia Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
description	Traditional cell lines and xenograft models have been widely recognized and used in research. As a new research model, organoids have made significant progress and development in the past 10 years. Compared with traditional models, organoids have more advantages and have been applied in cancer research, genetic diseases, infectious diseases, and regenerative medicine. This review presented the advantages and disadvantages of organoids in physiological development, pathological mechanism, drug screening, and organ transplantation. Further, this review summarized the current situation of vascularization, immune microenvironment, and hydrogel, which are the main influencing factors of organoids, and pointed out the future directions of development.
format	article
author	Yisheng Huang Zhijie Huang Zhengming Tang Yuanxin Chen Mingshu Huang Hongyu Liu Weibo Huang Qingsong Ye Qingsong Ye Bo Jia
author_facet	Yisheng Huang Zhijie Huang Zhengming Tang Yuanxin Chen Mingshu Huang Hongyu Liu Weibo Huang Qingsong Ye Qingsong Ye Bo Jia
author_sort	Yisheng Huang
title	Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_short	Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_full	Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_fullStr	Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_full_unstemmed	Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_sort	research progress, challenges, and breakthroughs of organoids as disease models
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f913016dfc5a486fba90ffd24e01810c
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_version_	1718426702332297216

Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models

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