Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury

Ischemia-reperfusion (I/R) is a pathological process that occurs in many organs and diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion injury. Drug therapy and early reperfusion therapy can reduce tissue injury and cell necrosis caused by ischemia, leading to...

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Autores principales:	Xinye Li, Ning Ma, Juping Xu, Yanchi Zhang, Pan Yang, Xin Su, Yanfeng Xing, Na An, Fan Yang, Guoxia Zhang, Lijing Zhang, Yanwei Xing
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/f913e1ed6d1e4623b47ba4e986f43a48
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spelling	oai:doaj.org-article:f913e1ed6d1e4623b47ba4e986f43a482021-11-08T02:36:17ZTargeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury1942-099410.1155/2021/1587922https://doaj.org/article/f913e1ed6d1e4623b47ba4e986f43a482021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1587922https://doaj.org/toc/1942-0994Ischemia-reperfusion (I/R) is a pathological process that occurs in many organs and diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion injury. Drug therapy and early reperfusion therapy can reduce tissue injury and cell necrosis caused by ischemia, leading to irreversible I/R injury. Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. Ferroptosis is a key factor that leads to I/R injury and organ failure. Given the important role of ferroptosis in I/R injury, there is considerable interest in the potential role of ferroptosis as a targeted treatment for a wide range of I/R injury-related diseases. Recently, substantial progress has been made in applying ferroptosis to I/R injury in various organs and diseases. The development of ferroptosis regulators is expected to provide new opportunities for the treatment of I/R injury. Herein, we analytically review the pathological mechanism and targeted treatment of ferroptosis in I/R and related diseases from the perspectives of myocardial I/R injury, cerebral I/R injury, and ischemic renal injury.Xinye LiNing MaJuping XuYanchi ZhangPan YangXin SuYanfeng XingNa AnFan YangGuoxia ZhangLijing ZhangYanwei XingHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Xinye Li Ning Ma Juping Xu Yanchi Zhang Pan Yang Xin Su Yanfeng Xing Na An Fan Yang Guoxia Zhang Lijing Zhang Yanwei Xing Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury
description	Ischemia-reperfusion (I/R) is a pathological process that occurs in many organs and diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion injury. Drug therapy and early reperfusion therapy can reduce tissue injury and cell necrosis caused by ischemia, leading to irreversible I/R injury. Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. Ferroptosis is a key factor that leads to I/R injury and organ failure. Given the important role of ferroptosis in I/R injury, there is considerable interest in the potential role of ferroptosis as a targeted treatment for a wide range of I/R injury-related diseases. Recently, substantial progress has been made in applying ferroptosis to I/R injury in various organs and diseases. The development of ferroptosis regulators is expected to provide new opportunities for the treatment of I/R injury. Herein, we analytically review the pathological mechanism and targeted treatment of ferroptosis in I/R and related diseases from the perspectives of myocardial I/R injury, cerebral I/R injury, and ischemic renal injury.
format	article
author	Xinye Li Ning Ma Juping Xu Yanchi Zhang Pan Yang Xin Su Yanfeng Xing Na An Fan Yang Guoxia Zhang Lijing Zhang Yanwei Xing
author_facet	Xinye Li Ning Ma Juping Xu Yanchi Zhang Pan Yang Xin Su Yanfeng Xing Na An Fan Yang Guoxia Zhang Lijing Zhang Yanwei Xing
author_sort	Xinye Li
title	Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury
title_short	Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury
title_full	Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury
title_fullStr	Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury
title_full_unstemmed	Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury
title_sort	targeting ferroptosis: pathological mechanism and treatment of ischemia-reperfusion injury
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/f913e1ed6d1e4623b47ba4e986f43a48
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Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury

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