An ultra-stable cytoplasmic antibody engineered for in vivo applications

An ultra-stable cytoplasmic antibody engineered for in vivo applications

Antibodies expressed in the cytosol often form insoluble aggregates, which makes it hard to target intracellular proteins. Here the authors engineer an ultra-stable cytoplasmic antibody (STAND) with a low isoelectric point that can be used in vivo.

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Autores principales: Hiroyuki Kabayama, Makoto Takeuchi, Naoko Tokushige, Shin-ichi Muramatsu, Miyuki Kabayama, Mitsunori Fukuda, Yoshiyuki Yamada, Katsuhiko Mikoshiba
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/f9143607edfe4e95b8e2df11ca430e7f
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spelling oai:doaj.org-article:f9143607edfe4e95b8e2df11ca430e7f2021-12-02T14:40:42ZAn ultra-stable cytoplasmic antibody engineered for in vivo applications10.1038/s41467-019-13654-92041-1723https://doaj.org/article/f9143607edfe4e95b8e2df11ca430e7f2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13654-9https://doaj.org/toc/2041-1723Antibodies expressed in the cytosol often form insoluble aggregates, which makes it hard to target intracellular proteins. Here the authors engineer an ultra-stable cytoplasmic antibody (STAND) with a low isoelectric point that can be used in vivo.Hiroyuki KabayamaMakoto TakeuchiNaoko TokushigeShin-ichi MuramatsuMiyuki KabayamaMitsunori FukudaYoshiyuki YamadaKatsuhiko MikoshibaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hiroyuki Kabayama
Makoto Takeuchi
Naoko Tokushige
Shin-ichi Muramatsu
Miyuki Kabayama
Mitsunori Fukuda
Yoshiyuki Yamada
Katsuhiko Mikoshiba
An ultra-stable cytoplasmic antibody engineered for in vivo applications
description Antibodies expressed in the cytosol often form insoluble aggregates, which makes it hard to target intracellular proteins. Here the authors engineer an ultra-stable cytoplasmic antibody (STAND) with a low isoelectric point that can be used in vivo.
format article
author Hiroyuki Kabayama
Makoto Takeuchi
Naoko Tokushige
Shin-ichi Muramatsu
Miyuki Kabayama
Mitsunori Fukuda
Yoshiyuki Yamada
Katsuhiko Mikoshiba
author_facet Hiroyuki Kabayama
Makoto Takeuchi
Naoko Tokushige
Shin-ichi Muramatsu
Miyuki Kabayama
Mitsunori Fukuda
Yoshiyuki Yamada
Katsuhiko Mikoshiba
author_sort Hiroyuki Kabayama
title An ultra-stable cytoplasmic antibody engineered for in vivo applications
title_short An ultra-stable cytoplasmic antibody engineered for in vivo applications
title_full An ultra-stable cytoplasmic antibody engineered for in vivo applications
title_fullStr An ultra-stable cytoplasmic antibody engineered for in vivo applications
title_full_unstemmed An ultra-stable cytoplasmic antibody engineered for in vivo applications
title_sort ultra-stable cytoplasmic antibody engineered for in vivo applications
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f9143607edfe4e95b8e2df11ca430e7f
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