A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers

A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers

Mapping transcription factors (TFs) occupancy is essential for understanding transcriptional programs. Here the authors use biotinylated knockin alleles of key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to map their genome-wide occupancy in the fetal and adult mouse heart, providing...

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Autores principales: Brynn N. Akerberg, Fei Gu, Nathan J. VanDusen, Xiaoran Zhang, Rui Dong, Kai Li, Bing Zhang, Bin Zhou, Isha Sethi, Qing Ma, Lauren Wasson, Tong Wen, Jinhua Liu, Kunzhe Dong, Frank L. Conlon, Jiliang Zhou, Guo-Cheng Yuan, Pingzhu Zhou, William T. Pu
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f91597d9ab8045b0bc0e2854890b31e1
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spelling oai:doaj.org-article:f91597d9ab8045b0bc0e2854890b31e12021-12-02T17:31:53ZA reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers10.1038/s41467-019-12812-32041-1723https://doaj.org/article/f91597d9ab8045b0bc0e2854890b31e12019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12812-3https://doaj.org/toc/2041-1723Mapping transcription factors (TFs) occupancy is essential for understanding transcriptional programs. Here the authors use biotinylated knockin alleles of key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to map their genome-wide occupancy in the fetal and adult mouse heart, providing insight into the cardiac transcriptional regulatory network.Brynn N. AkerbergFei GuNathan J. VanDusenXiaoran ZhangRui DongKai LiBing ZhangBin ZhouIsha SethiQing MaLauren WassonTong WenJinhua LiuKunzhe DongFrank L. ConlonJiliang ZhouGuo-Cheng YuanPingzhu ZhouWilliam T. PuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Brynn N. Akerberg
Fei Gu
Nathan J. VanDusen
Xiaoran Zhang
Rui Dong
Kai Li
Bing Zhang
Bin Zhou
Isha Sethi
Qing Ma
Lauren Wasson
Tong Wen
Jinhua Liu
Kunzhe Dong
Frank L. Conlon
Jiliang Zhou
Guo-Cheng Yuan
Pingzhu Zhou
William T. Pu
A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
description Mapping transcription factors (TFs) occupancy is essential for understanding transcriptional programs. Here the authors use biotinylated knockin alleles of key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to map their genome-wide occupancy in the fetal and adult mouse heart, providing insight into the cardiac transcriptional regulatory network.
format article
author Brynn N. Akerberg
Fei Gu
Nathan J. VanDusen
Xiaoran Zhang
Rui Dong
Kai Li
Bing Zhang
Bin Zhou
Isha Sethi
Qing Ma
Lauren Wasson
Tong Wen
Jinhua Liu
Kunzhe Dong
Frank L. Conlon
Jiliang Zhou
Guo-Cheng Yuan
Pingzhu Zhou
William T. Pu
author_facet Brynn N. Akerberg
Fei Gu
Nathan J. VanDusen
Xiaoran Zhang
Rui Dong
Kai Li
Bing Zhang
Bin Zhou
Isha Sethi
Qing Ma
Lauren Wasson
Tong Wen
Jinhua Liu
Kunzhe Dong
Frank L. Conlon
Jiliang Zhou
Guo-Cheng Yuan
Pingzhu Zhou
William T. Pu
author_sort Brynn N. Akerberg
title A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
title_short A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
title_full A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
title_fullStr A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
title_full_unstemmed A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
title_sort reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/f91597d9ab8045b0bc0e2854890b31e1
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