A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs). Here the authors develop CC-seq—a method that allows direct mapping of both Top2-linked SSBs...

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Autores principales: William H. Gittens, Dominic J. Johnson, Rachal M. Allison, Tim J. Cooper, Holly Thomas, Matthew J. Neale
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/f91830fdb6fb441087a9822e5cdba14e
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