Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects

Naim Terai, Matthias M&uuml;ller-Holz, Eberhard Spoerl, Lutz E PillunatDepartment of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, GermanyBackground: The purpose of this study was to investigate the short-term effect of topical antiglaucoma medication on tear-film stability,...

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Autores principales:	Pillunat LE, Spoerl E, M&uuml;ller-Holz M, Terai N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f919bd69b03f4de7931e2a0d4a655a6b
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spelling	oai:doaj.org-article:f919bd69b03f4de7931e2a0d4a655a6b2021-12-02T01:08:39ZShort-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects1177-54671177-5483https://doaj.org/article/f919bd69b03f4de7931e2a0d4a655a6b2011-04-01T00:00:00Zhttp://www.dovepress.com/short-term-effect-of-topical-antiglaucoma-medication-on-tear-film-stab-a7233https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Naim Terai, Matthias M&uuml;ller-Holz, Eberhard Spoerl, Lutz E PillunatDepartment of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, GermanyBackground: The purpose of this study was to investigate the short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects.Methods: In this prospective, double-blind crossover trial, break-up time and basal secretion (Jones test) were measured 60 minutes before, and 30, 60, and 90 minutes after topical antiglaucoma drop application in 30 healthy subjects. Corneal sensitivity was measured 60 minutes before, and five, 10, and 15 minutes after drop application using a Cochet&ndash;Bonnet esthesiometer.Results: Reduction of break-up time in the latanoprost group was -23.8% after 30 minutes (P = 0.21), -26.7% after 60 minutes (P = 0.03) and -51.4% after 90 minutes (P &le; 0.003), which was statistically significant. Reduction of break-up time in all other treatment groups was not statistically significant. The Jones test revealed a significant reduction of basal secretion after application of brimonidine (-17.8%, P = 0.002; -22.5%, P&lt; 0.001; -30.5%, P &lt; 0.001), followed by apraclonidine (-10%, P = 0.06; -20.1%, P = 0.02; -22.1%, P = 0.002), latanoprost (-2.4%, P = 0.64; -18.6%, P = 0.001; -20.1%, P = 0.001) and dorzolamide (-0.5%, P = 0.9; 14.3%, P = 0.018; -17.3%, P = 0.004) at 30, 60, and 90 minutes after drop application. Reduction of basal secretion in all other treatment groups was not statistically significant.Conclusion: Latanoprost showed the most statistically significant reduction in break-up time, and brimonidine showed the most significant reduction in basal secretion of all the glaucoma medications used in this study. In conclusion, our data may be helpful for treatment decisions in glaucoma patients who also suffer from ocular surface problems.Keywords: tear-film, tear secretion, corneal sensitivity, antiglaucoma medicationPillunat LESpoerl EM&uuml;ller-Holz MTerai NDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 517-525 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Pillunat LE Spoerl E M&uuml;ller-Holz M Terai N Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects
description	Naim Terai, Matthias M&uuml;ller-Holz, Eberhard Spoerl, Lutz E PillunatDepartment of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, GermanyBackground: The purpose of this study was to investigate the short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects.Methods: In this prospective, double-blind crossover trial, break-up time and basal secretion (Jones test) were measured 60 minutes before, and 30, 60, and 90 minutes after topical antiglaucoma drop application in 30 healthy subjects. Corneal sensitivity was measured 60 minutes before, and five, 10, and 15 minutes after drop application using a Cochet&ndash;Bonnet esthesiometer.Results: Reduction of break-up time in the latanoprost group was -23.8% after 30 minutes (P = 0.21), -26.7% after 60 minutes (P = 0.03) and -51.4% after 90 minutes (P &le; 0.003), which was statistically significant. Reduction of break-up time in all other treatment groups was not statistically significant. The Jones test revealed a significant reduction of basal secretion after application of brimonidine (-17.8%, P = 0.002; -22.5%, P&lt; 0.001; -30.5%, P &lt; 0.001), followed by apraclonidine (-10%, P = 0.06; -20.1%, P = 0.02; -22.1%, P = 0.002), latanoprost (-2.4%, P = 0.64; -18.6%, P = 0.001; -20.1%, P = 0.001) and dorzolamide (-0.5%, P = 0.9; 14.3%, P = 0.018; -17.3%, P = 0.004) at 30, 60, and 90 minutes after drop application. Reduction of basal secretion in all other treatment groups was not statistically significant.Conclusion: Latanoprost showed the most statistically significant reduction in break-up time, and brimonidine showed the most significant reduction in basal secretion of all the glaucoma medications used in this study. In conclusion, our data may be helpful for treatment decisions in glaucoma patients who also suffer from ocular surface problems.Keywords: tear-film, tear secretion, corneal sensitivity, antiglaucoma medication
format	article
author	Pillunat LE Spoerl E M&uuml;ller-Holz M Terai N
author_facet	Pillunat LE Spoerl E M&uuml;ller-Holz M Terai N
author_sort	Pillunat LE
title	Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects
title_short	Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects
title_full	Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects
title_fullStr	Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects
title_full_unstemmed	Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects
title_sort	short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/f919bd69b03f4de7931e2a0d4a655a6b
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Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects

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