Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy

Abstract Although the clinical practice guideline for outpatient management of febrile neutropenia (FN) in adults treated for malignancy was updated by the ASCO/IDSA in 2018, most patients with FN in our hospital have been hospitalized. We performed this study to analyze the usefulness of the guidel...

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Autores principales:	Soyoon Hwang, Ki Tae Kwon, Yoonjung Kim, Sohyun Bae, Hyun-Ha Chang, Shin-Woo Kim, Seung Soo Yoo, Su Youn Nam, Jin Ho Baek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f91bdc896cda4462bce3c7a65865e06d
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spelling	oai:doaj.org-article:f91bdc896cda4462bce3c7a65865e06d2021-12-02T15:15:45ZUsefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy10.1038/s41598-021-88207-62045-2322https://doaj.org/article/f91bdc896cda4462bce3c7a65865e06d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88207-6https://doaj.org/toc/2045-2322Abstract Although the clinical practice guideline for outpatient management of febrile neutropenia (FN) in adults treated for malignancy was updated by the ASCO/IDSA in 2018, most patients with FN in our hospital have been hospitalized. We performed this study to analyze the usefulness of the guideline. The medical records of patients hospitalized for FN in Kyungpook National University Chilgok Hospital from May 2016 to April 2018 were retrospectively reviewed. The feasibility of candidates for outpatient management according to the guideline was evaluated based on the outcomes. A total of 114 patients were enrolled and categorized into two groups, low-risk (38.6%) and high-risk (61.4%). The proportion of feasible candidates for outpatient management was 70.2% and was higher in the low-risk than in the high-risk group (90.0% vs. 57.1%; P < 0.001). The low-risk group had no mortality, no resistance to oral amoxicillin/clavulanate or ciprofloxacin, a higher rate of successful empirical antibiotics, and lower rates of glycopeptide or carbapenem administration. A significant number of hospitalized cancer patients treated for FN after chemotherapy were found to be feasible candidates for outpatient management. The guideline can be a useful tool to reduce labor of healthcare workers and hospitalization costs.Soyoon HwangKi Tae KwonYoonjung KimSohyun BaeHyun-Ha ChangShin-Woo KimSeung Soo YooSu Youn NamJin Ho BaekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soyoon Hwang Ki Tae Kwon Yoonjung Kim Sohyun Bae Hyun-Ha Chang Shin-Woo Kim Seung Soo Yoo Su Youn Nam Jin Ho Baek Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy
description	Abstract Although the clinical practice guideline for outpatient management of febrile neutropenia (FN) in adults treated for malignancy was updated by the ASCO/IDSA in 2018, most patients with FN in our hospital have been hospitalized. We performed this study to analyze the usefulness of the guideline. The medical records of patients hospitalized for FN in Kyungpook National University Chilgok Hospital from May 2016 to April 2018 were retrospectively reviewed. The feasibility of candidates for outpatient management according to the guideline was evaluated based on the outcomes. A total of 114 patients were enrolled and categorized into two groups, low-risk (38.6%) and high-risk (61.4%). The proportion of feasible candidates for outpatient management was 70.2% and was higher in the low-risk than in the high-risk group (90.0% vs. 57.1%; P < 0.001). The low-risk group had no mortality, no resistance to oral amoxicillin/clavulanate or ciprofloxacin, a higher rate of successful empirical antibiotics, and lower rates of glycopeptide or carbapenem administration. A significant number of hospitalized cancer patients treated for FN after chemotherapy were found to be feasible candidates for outpatient management. The guideline can be a useful tool to reduce labor of healthcare workers and hospitalization costs.
format	article
author	Soyoon Hwang Ki Tae Kwon Yoonjung Kim Sohyun Bae Hyun-Ha Chang Shin-Woo Kim Seung Soo Yoo Su Youn Nam Jin Ho Baek
author_facet	Soyoon Hwang Ki Tae Kwon Yoonjung Kim Sohyun Bae Hyun-Ha Chang Shin-Woo Kim Seung Soo Yoo Su Youn Nam Jin Ho Baek
author_sort	Soyoon Hwang
title	Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy
title_short	Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy
title_full	Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy
title_fullStr	Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy
title_full_unstemmed	Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy
title_sort	usefulness analysis of the 2018 asco/idsa guideline for outpatient management of fever and neutropenia in adults treated for malignancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f91bdc896cda4462bce3c7a65865e06d
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Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy

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