Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns

Drug-coated balloons (DCBs) have become an established therapy for the treatment of above-the-knee peripheral artery disease. The paclitaxel DCB has shown clinical benefit in terms of patency and freedom from re-intervention in multiple randomised trials. However, a recent meta-analysis has suggeste...

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Autores principales:	Masayuki Mori, Atsushi Sakamoto, Rika Kawakami, Yu Sato, Hiroyuki Jinnouchi, Kenji Kawai, Anne Cornelissen, Renu Virmani, Aloke V Finn
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/f91c206208b44a8a880d3e366e62a358
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spelling	oai:doaj.org-article:f91c206208b44a8a880d3e366e62a3582021-12-04T16:04:13ZPaclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns10.15420/ver.2020.162516-33022516-3299https://doaj.org/article/f91c206208b44a8a880d3e366e62a3582021-04-01T00:00:00Zhttps://www.verjournal.com/articles/paclitaxel-and-sirolimus-coated-balloonshttps://doaj.org/toc/2516-3299https://doaj.org/toc/2516-3302Drug-coated balloons (DCBs) have become an established therapy for the treatment of above-the-knee peripheral artery disease. The paclitaxel DCB has shown clinical benefit in terms of patency and freedom from re-intervention in multiple randomised trials. However, a recent meta-analysis has suggested an association between mortality and the use of paclitaxel-coated devices. Sirolimus is another potential choice of anti-proliferative agent for use in DCBs because of its wider therapeutic index and lower risk for dose-dependent toxicity. More recently, encapsulating sirolimus in micro-reservoirs or polymers has facilitated the development of effective sirolimus DCBs, some of which are available in Europe and Asia. In this review, the authors focus on paclitaxel and sirolimus DCB technologies from the standpoint of drug characteristics and clinical trials.Masayuki MoriAtsushi SakamotoRika KawakamiYu SatoHiroyuki JinnouchiKenji KawaiAnne CornelissenRenu VirmaniAloke V FinnRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENVascular and Endovascular Review , Vol 4, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Masayuki Mori Atsushi Sakamoto Rika Kawakami Yu Sato Hiroyuki Jinnouchi Kenji Kawai Anne Cornelissen Renu Virmani Aloke V Finn Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns
description	Drug-coated balloons (DCBs) have become an established therapy for the treatment of above-the-knee peripheral artery disease. The paclitaxel DCB has shown clinical benefit in terms of patency and freedom from re-intervention in multiple randomised trials. However, a recent meta-analysis has suggested an association between mortality and the use of paclitaxel-coated devices. Sirolimus is another potential choice of anti-proliferative agent for use in DCBs because of its wider therapeutic index and lower risk for dose-dependent toxicity. More recently, encapsulating sirolimus in micro-reservoirs or polymers has facilitated the development of effective sirolimus DCBs, some of which are available in Europe and Asia. In this review, the authors focus on paclitaxel and sirolimus DCB technologies from the standpoint of drug characteristics and clinical trials.
format	article
author	Masayuki Mori Atsushi Sakamoto Rika Kawakami Yu Sato Hiroyuki Jinnouchi Kenji Kawai Anne Cornelissen Renu Virmani Aloke V Finn
author_facet	Masayuki Mori Atsushi Sakamoto Rika Kawakami Yu Sato Hiroyuki Jinnouchi Kenji Kawai Anne Cornelissen Renu Virmani Aloke V Finn
author_sort	Masayuki Mori
title	Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns
title_short	Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns
title_full	Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns
title_fullStr	Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns
title_full_unstemmed	Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns
title_sort	paclitaxel- and sirolimus-coated balloons in peripheral artery disease treatment: current perspectives and concerns
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/f91c206208b44a8a880d3e366e62a358
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Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns

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