A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System

Of all malignant brain tumors, glioma is the deadliest and most common, with a poor prognosis. Drug therapy is considered as a promising way to stop the progression of disease and even cure tumors. However, the presence of blood brain barrier (BBB) and blood tumor barrier (BTB) limits the delivery o...

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Autores principales:	Keqi Hu, Daquan Zhou, Linlin Rao, Peng Wang, Chunxiang Xiang, Feng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	drug delivery aggregation-induced emission imaging PLA-PEG T7 peptide cancer treatment Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/f91db9f18e264b2dac19c96793a4b89c
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spelling	oai:doaj.org-article:f91db9f18e264b2dac19c96793a4b89c2021-11-08T07:22:06ZA Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System2296-418510.3389/fbioe.2021.766470https://doaj.org/article/f91db9f18e264b2dac19c96793a4b89c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.766470/fullhttps://doaj.org/toc/2296-4185Of all malignant brain tumors, glioma is the deadliest and most common, with a poor prognosis. Drug therapy is considered as a promising way to stop the progression of disease and even cure tumors. However, the presence of blood brain barrier (BBB) and blood tumor barrier (BTB) limits the delivery of these therapeutic genes. In this work, an intelligent cell imaging and cancer therapy drug delivery system targeting the blood-brain barrier and the highly expressed transferrin receptors (TfR) in gliomas has been successfully constructed, and an amphiphilic polymer (PLA-PEG-T7/TPE) with aggregation-induced emission (AIE) properties has been designed and successfully synthesized. PLA-PEG-T7/TPE self-assembled polymer micelles showed significant AIE effect in aqueous solution with good biocompatibility. Therefore, it can be used for potential biological imaging applications. In addition, drug-carrying micelles showed typical behavior of regulating drug release. Inhibition of cell proliferation in vitro showed that the drug-loaded micelles had dose-dependent cytotoxicity to LN229 cells. In the in vivo anti-tumor experiment, PLA-PEG-T7/TPE/TMZ had the best therapeutic effect. These results indicated that T7 functionalized PLA-PEG was a promising platform for nasopharyngeal cancer drug combination therapy.Keqi HuDaquan ZhouLinlin RaoPeng WangChunxiang XiangFeng ChenFrontiers Media S.A.articledrug deliveryaggregation-induced emissionimagingPLA-PEGT7 peptidecancer treatmentBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery aggregation-induced emission imaging PLA-PEG T7 peptide cancer treatment Biotechnology TP248.13-248.65
spellingShingle	drug delivery aggregation-induced emission imaging PLA-PEG T7 peptide cancer treatment Biotechnology TP248.13-248.65 Keqi Hu Daquan Zhou Linlin Rao Peng Wang Chunxiang Xiang Feng Chen A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System
description	Of all malignant brain tumors, glioma is the deadliest and most common, with a poor prognosis. Drug therapy is considered as a promising way to stop the progression of disease and even cure tumors. However, the presence of blood brain barrier (BBB) and blood tumor barrier (BTB) limits the delivery of these therapeutic genes. In this work, an intelligent cell imaging and cancer therapy drug delivery system targeting the blood-brain barrier and the highly expressed transferrin receptors (TfR) in gliomas has been successfully constructed, and an amphiphilic polymer (PLA-PEG-T7/TPE) with aggregation-induced emission (AIE) properties has been designed and successfully synthesized. PLA-PEG-T7/TPE self-assembled polymer micelles showed significant AIE effect in aqueous solution with good biocompatibility. Therefore, it can be used for potential biological imaging applications. In addition, drug-carrying micelles showed typical behavior of regulating drug release. Inhibition of cell proliferation in vitro showed that the drug-loaded micelles had dose-dependent cytotoxicity to LN229 cells. In the in vivo anti-tumor experiment, PLA-PEG-T7/TPE/TMZ had the best therapeutic effect. These results indicated that T7 functionalized PLA-PEG was a promising platform for nasopharyngeal cancer drug combination therapy.
format	article
author	Keqi Hu Daquan Zhou Linlin Rao Peng Wang Chunxiang Xiang Feng Chen
author_facet	Keqi Hu Daquan Zhou Linlin Rao Peng Wang Chunxiang Xiang Feng Chen
author_sort	Keqi Hu
title	A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System
title_short	A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System
title_full	A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System
title_fullStr	A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System
title_full_unstemmed	A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System
title_sort	multifunctional aie nanoprobe as a drug delivery bioimaging and cancer treatment system
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f91db9f18e264b2dac19c96793a4b89c
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A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System

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