The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents

Abstract miRNAs, a class of short but stable noncoding RNA molecules, have been revealed to play important roles in the DNA damage response (DDR). However, their functions in cancer genome instability and the consequent clinical effect as the response to chemotherapy have not been fully elucidated....

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Autores principales:	Tianzhen Wang, Guangyu Wang, Xiaoxiao Zhang, Di Wu, Lei Yang, Guangyou Wang, Dapeng Hao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f923c5b8762748269d79904626c120e4
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spelling	oai:doaj.org-article:f923c5b8762748269d79904626c120e42021-12-02T15:05:11ZThe expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents10.1038/s41598-017-12259-w2045-2322https://doaj.org/article/f923c5b8762748269d79904626c120e42017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-12259-whttps://doaj.org/toc/2045-2322Abstract miRNAs, a class of short but stable noncoding RNA molecules, have been revealed to play important roles in the DNA damage response (DDR). However, their functions in cancer genome instability and the consequent clinical effect as the response to chemotherapy have not been fully elucidated. In this study, we utilized multidimensional TCGA data and the known miRNAs involved in DDR to identify a miRNA-regulatory network that responds to DNA damage. Additionally, based on the expression of ten miRNAs in this network, we developed a 10-miRNA-score that predicts defects in the homologous recombination (HR) pathway and genome instability in ovarian cancer. Importantly, consistent with the association between HR defects and improved response to chemotherapeutic agents, the 10-miRNA-score predicts the outcome of ovarian cancer patients treated with platinum agents, with a surprisingly better performance than the indexes of DNA damage. Therefore, our study demonstrates the implication of miRNA expression on cancer genome instability and provides an alternative method to identify DDR defects in patients who show the best effect with platinum drug treatment.Tianzhen WangGuangyu WangXiaoxiao ZhangDi WuLei YangGuangyou WangDapeng HaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tianzhen Wang Guangyu Wang Xiaoxiao Zhang Di Wu Lei Yang Guangyou Wang Dapeng Hao The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
description	Abstract miRNAs, a class of short but stable noncoding RNA molecules, have been revealed to play important roles in the DNA damage response (DDR). However, their functions in cancer genome instability and the consequent clinical effect as the response to chemotherapy have not been fully elucidated. In this study, we utilized multidimensional TCGA data and the known miRNAs involved in DDR to identify a miRNA-regulatory network that responds to DNA damage. Additionally, based on the expression of ten miRNAs in this network, we developed a 10-miRNA-score that predicts defects in the homologous recombination (HR) pathway and genome instability in ovarian cancer. Importantly, consistent with the association between HR defects and improved response to chemotherapeutic agents, the 10-miRNA-score predicts the outcome of ovarian cancer patients treated with platinum agents, with a surprisingly better performance than the indexes of DNA damage. Therefore, our study demonstrates the implication of miRNA expression on cancer genome instability and provides an alternative method to identify DDR defects in patients who show the best effect with platinum drug treatment.
format	article
author	Tianzhen Wang Guangyu Wang Xiaoxiao Zhang Di Wu Lei Yang Guangyou Wang Dapeng Hao
author_facet	Tianzhen Wang Guangyu Wang Xiaoxiao Zhang Di Wu Lei Yang Guangyou Wang Dapeng Hao
author_sort	Tianzhen Wang
title	The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
title_short	The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
title_full	The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
title_fullStr	The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
title_full_unstemmed	The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
title_sort	expression of mirnas is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f923c5b8762748269d79904626c120e4
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The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents

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