Brain oscillations in bipolar disorder and lithium-induced changes

Murat İlhan Atagün Department of Psychiatry, Yıldırım Beyazıt University Medical School, Cankaya, Ankara, Turkey Abstract: Electroencephalography (EEG) studies in patients with bipolar disorder have revealed lower amplitudes in brain oscillations. The aim of this review is to describe lit...

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Autor principal:	Atagün Mİ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	lithium bipolar disorder brain oscillations neuroplasticity biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f9262912c031494ab595cf0d8d93660b
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spelling	oai:doaj.org-article:f9262912c031494ab595cf0d8d93660b2021-12-02T02:43:20ZBrain oscillations in bipolar disorder and lithium-induced changes1178-2021https://doaj.org/article/f9262912c031494ab595cf0d8d93660b2016-03-01T00:00:00Zhttps://www.dovepress.com/brain-oscillations-in-bipolar-disorder-andnbsplithium-induced-changes-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Murat İlhan Atagün Department of Psychiatry, Yıldırım Beyazıt University Medical School, Cankaya, Ankara, Turkey Abstract: Electroencephalography (EEG) studies in patients with bipolar disorder have revealed lower amplitudes in brain oscillations. The aim of this review is to describe lithium-induced EEG changes in bipolar disorder and to discuss potential underlying factors. A literature survey about lithium-induced EEG changes in bipolar disorder was performed. Lithium consistently enhances magnitudes of brain oscillations in slow frequencies (delta and theta) in both resting-state EEG studies as well as event-related oscillations studies. Enhancement of magnitudes of beta oscillations is specific to event-related oscillations. Correlation between serum lithium levels and brain oscillations has been reported. Lithium-induced changes in brain oscillations might correspond to lithium-induced alterations in neurotransmitters, signaling cascades, plasticity, brain structure, or biophysical properties of lithium. Therefore, lithium-induced changes in brain oscillations could be promising biomarkers to assess the molecular mechanisms leading to variability in efficacy. Since the variability of lithium response in bipolar disorder is due to the genetic differences in the mechanisms involving lithium, it would be highly promising to assess the lithium-induced EEG changes as biomarkers in genetic studies. Keywords: lithium, bipolar disorder, brain oscillations, electroencephalography, biomarkerAtagün MİDove Medical Pressarticlelithiumbipolar disorderbrain oscillationsneuroplasticitybiomarkerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 589-601 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	lithium bipolar disorder brain oscillations neuroplasticity biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	lithium bipolar disorder brain oscillations neuroplasticity biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Atagün Mİ Brain oscillations in bipolar disorder and lithium-induced changes
description	Murat İlhan Atagün Department of Psychiatry, Yıldırım Beyazıt University Medical School, Cankaya, Ankara, Turkey Abstract: Electroencephalography (EEG) studies in patients with bipolar disorder have revealed lower amplitudes in brain oscillations. The aim of this review is to describe lithium-induced EEG changes in bipolar disorder and to discuss potential underlying factors. A literature survey about lithium-induced EEG changes in bipolar disorder was performed. Lithium consistently enhances magnitudes of brain oscillations in slow frequencies (delta and theta) in both resting-state EEG studies as well as event-related oscillations studies. Enhancement of magnitudes of beta oscillations is specific to event-related oscillations. Correlation between serum lithium levels and brain oscillations has been reported. Lithium-induced changes in brain oscillations might correspond to lithium-induced alterations in neurotransmitters, signaling cascades, plasticity, brain structure, or biophysical properties of lithium. Therefore, lithium-induced changes in brain oscillations could be promising biomarkers to assess the molecular mechanisms leading to variability in efficacy. Since the variability of lithium response in bipolar disorder is due to the genetic differences in the mechanisms involving lithium, it would be highly promising to assess the lithium-induced EEG changes as biomarkers in genetic studies. Keywords: lithium, bipolar disorder, brain oscillations, electroencephalography, biomarker
format	article
author	Atagün Mİ
author_facet	Atagün Mİ
author_sort	Atagün Mİ
title	Brain oscillations in bipolar disorder and lithium-induced changes
title_short	Brain oscillations in bipolar disorder and lithium-induced changes
title_full	Brain oscillations in bipolar disorder and lithium-induced changes
title_fullStr	Brain oscillations in bipolar disorder and lithium-induced changes
title_full_unstemmed	Brain oscillations in bipolar disorder and lithium-induced changes
title_sort	brain oscillations in bipolar disorder and lithium-induced changes
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f9262912c031494ab595cf0d8d93660b
work_keys_str_mv	AT ataguumlnmi brainoscillationsinbipolardisorderandnbsplithiuminducedchanges
_version_	1718402260729331712

Brain oscillations in bipolar disorder and&nbsp;lithium-induced changes

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