Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding

Co-translational protein folding is thought to occur at equilibrium for fast-folding domains. Here authors use optical tweezers to show that the folding kinetics of stalled ribosome-bound nascent chains do not match the folding of nascent chains in real time.

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Autores principales:	Lisa M. Alexander, Daniel H. Goldman, Liang M. Wee, Carlos Bustamante
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f9264d0911464f1592eb28ce35717797
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spelling	oai:doaj.org-article:f9264d0911464f1592eb28ce357177972021-12-02T15:36:03ZNon-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding10.1038/s41467-019-10647-62041-1723https://doaj.org/article/f9264d0911464f1592eb28ce357177972019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10647-6https://doaj.org/toc/2041-1723Co-translational protein folding is thought to occur at equilibrium for fast-folding domains. Here authors use optical tweezers to show that the folding kinetics of stalled ribosome-bound nascent chains do not match the folding of nascent chains in real time.Lisa M. AlexanderDaniel H. GoldmanLiang M. WeeCarlos BustamanteNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lisa M. Alexander Daniel H. Goldman Liang M. Wee Carlos Bustamante Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
description	Co-translational protein folding is thought to occur at equilibrium for fast-folding domains. Here authors use optical tweezers to show that the folding kinetics of stalled ribosome-bound nascent chains do not match the folding of nascent chains in real time.
format	article
author	Lisa M. Alexander Daniel H. Goldman Liang M. Wee Carlos Bustamante
author_facet	Lisa M. Alexander Daniel H. Goldman Liang M. Wee Carlos Bustamante
author_sort	Lisa M. Alexander
title	Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
title_short	Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
title_full	Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
title_fullStr	Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
title_full_unstemmed	Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
title_sort	non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f9264d0911464f1592eb28ce35717797
work_keys_str_mv	AT lisamalexander nonequilibriumdynamicsofanascentpolypeptideduringtranslationsuppressitsmisfolding AT danielhgoldman nonequilibriumdynamicsofanascentpolypeptideduringtranslationsuppressitsmisfolding AT liangmwee nonequilibriumdynamicsofanascentpolypeptideduringtranslationsuppressitsmisfolding AT carlosbustamante nonequilibriumdynamicsofanascentpolypeptideduringtranslationsuppressitsmisfolding
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Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding

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