Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression

Master regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression through activating its super-enhancer, and CCAT1 fo...

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Autores principales:	Yuan Jiang, Yan-Yi Jiang, Jian-Jun Xie, Anand Mayakonda, Masaharu Hazawa, Li Chen, Jin-Fen Xiao, Chun-Quan Li, Mo-Li Huang, Ling-Wen Ding, Qiao-Yang Sun, Liang Xu, Deepika Kanojia, Maya Jeitany, Jian-Wen Deng, Lian-Di Liao, Harmik J. Soukiasian, Benjamin P. Berman, Jia-Jie Hao, Li-Yan Xu, En-Min Li, Ming-Rong Wang, Xin-Gang Bi, De-Chen Lin, H. Phillip Koeffler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f927ec3e43a241b38907cdd1a8dba8c5
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spelling	oai:doaj.org-article:f927ec3e43a241b38907cdd1a8dba8c52021-12-02T17:31:30ZCo-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression10.1038/s41467-018-06081-92041-1723https://doaj.org/article/f927ec3e43a241b38907cdd1a8dba8c52018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06081-9https://doaj.org/toc/2041-1723Master regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression through activating its super-enhancer, and CCAT1 forms a complex with TP63 and SOX2, which regulates EGFR super-enhancers and enhances both the MEK/ERK1/2 and PI3K/AKT signaling pathways in SCC.Yuan JiangYan-Yi JiangJian-Jun XieAnand MayakondaMasaharu HazawaLi ChenJin-Fen XiaoChun-Quan LiMo-Li HuangLing-Wen DingQiao-Yang SunLiang XuDeepika KanojiaMaya JeitanyJian-Wen DengLian-Di LiaoHarmik J. SoukiasianBenjamin P. BermanJia-Jie HaoLi-Yan XuEn-Min LiMing-Rong WangXin-Gang BiDe-Chen LinH. Phillip KoefflerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Jiang Yan-Yi Jiang Jian-Jun Xie Anand Mayakonda Masaharu Hazawa Li Chen Jin-Fen Xiao Chun-Quan Li Mo-Li Huang Ling-Wen Ding Qiao-Yang Sun Liang Xu Deepika Kanojia Maya Jeitany Jian-Wen Deng Lian-Di Liao Harmik J. Soukiasian Benjamin P. Berman Jia-Jie Hao Li-Yan Xu En-Min Li Ming-Rong Wang Xin-Gang Bi De-Chen Lin H. Phillip Koeffler Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
description	Master regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression through activating its super-enhancer, and CCAT1 forms a complex with TP63 and SOX2, which regulates EGFR super-enhancers and enhances both the MEK/ERK1/2 and PI3K/AKT signaling pathways in SCC.
format	article
author	Yuan Jiang Yan-Yi Jiang Jian-Jun Xie Anand Mayakonda Masaharu Hazawa Li Chen Jin-Fen Xiao Chun-Quan Li Mo-Li Huang Ling-Wen Ding Qiao-Yang Sun Liang Xu Deepika Kanojia Maya Jeitany Jian-Wen Deng Lian-Di Liao Harmik J. Soukiasian Benjamin P. Berman Jia-Jie Hao Li-Yan Xu En-Min Li Ming-Rong Wang Xin-Gang Bi De-Chen Lin H. Phillip Koeffler
author_facet	Yuan Jiang Yan-Yi Jiang Jian-Jun Xie Anand Mayakonda Masaharu Hazawa Li Chen Jin-Fen Xiao Chun-Quan Li Mo-Li Huang Ling-Wen Ding Qiao-Yang Sun Liang Xu Deepika Kanojia Maya Jeitany Jian-Wen Deng Lian-Di Liao Harmik J. Soukiasian Benjamin P. Berman Jia-Jie Hao Li-Yan Xu En-Min Li Ming-Rong Wang Xin-Gang Bi De-Chen Lin H. Phillip Koeffler
author_sort	Yuan Jiang
title	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
title_short	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
title_full	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
title_fullStr	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
title_full_unstemmed	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
title_sort	co-activation of super-enhancer-driven ccat1 by tp63 and sox2 promotes squamous cancer progression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f927ec3e43a241b38907cdd1a8dba8c5
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Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression

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