EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE

Objectives: To evaluate the principal risk factors associated with development of intrahepatic cholestasis of pregnancy (ICP) in patients presenting to a tertiary care hospital. Study Design: Case control study. Place and Duration of Study: Department of Gynaecology and Obstetrics, Pakistan Na...

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Autores principales:	Rabiah Anwar, Kashif Razzaq, Aysha Shahid, Afeera Afsheen, Amera Tariq, Irum Saleem
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	frequency intrahepatic cholestasis of pregnancy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f9287f355ea04c04960c5c75ddaf3c67
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spelling	oai:doaj.org-article:f9287f355ea04c04960c5c75ddaf3c672021-11-24T04:35:24ZEVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE0030-96482411-8842https://doaj.org/article/f9287f355ea04c04960c5c75ddaf3c672021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/5310/3636https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objectives: To evaluate the principal risk factors associated with development of intrahepatic cholestasis of pregnancy (ICP) in patients presenting to a tertiary care hospital. Study Design: Case control study. Place and Duration of Study: Department of Gynaecology and Obstetrics, Pakistan Naval Ship Shifa Hospital Karachi, from Jan to Dec 2019. Methodology: All pregnant women with symptoms of intrahepatic cholestasis of pregnancy confirmed on history, examination and investigations were included. A comparison cohort of pregnant women with neither hepatobiliary nor medical illness associated with pregnancy was selected. Comparison of risk factors was done between both the groups. Results: Out of 6932 obstetric patients, 90 (1.29%) had intrahepatic cholestasis of pregnancy. Pruritis was cardinal symptoms in all (100%) the patients followed by excoriation marks (75.55%). Intrahepatic cholestasis of pregnancy was significantly found in women with multiple pregnancy (OR=1.81; 95% CI 0.51-6.42), antecedent intrahepatic cholestasis of pregnancy (OR=36.81; 95% CI 8.53-158.79), family history of intrahepatic cholestasis of pregnancy (OR=17.80; 95% CI 2.29-137.91) and history of pruritis with obstetric cholestasis of pregnancy use (OR=16.25; 95% CI 0.91-289.08). Conclusion: Intrahepatic cholestasis of pregnancy was observed in less than two percent cases. Risk of intrahepatic cholestasis of pregnancy was found to be increased with multiple pregnancies, antecedent intrahepatic cholestasis of pregnancy, family history of intrahepatic cholestasis of pregnancy and history of pruritis with prior obstetric cholestasis of pregnancy use.Rabiah AnwarKashif RazzaqAysha ShahidAfeera AfsheenAmera TariqIrum SaleemArmy Medical College Rawalpindiarticlefrequencyintrahepatic cholestasis of pregnancyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1852-1856 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	frequency intrahepatic cholestasis of pregnancy Medicine R Medicine (General) R5-920
spellingShingle	frequency intrahepatic cholestasis of pregnancy Medicine R Medicine (General) R5-920 Rabiah Anwar Kashif Razzaq Aysha Shahid Afeera Afsheen Amera Tariq Irum Saleem EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE
description	Objectives: To evaluate the principal risk factors associated with development of intrahepatic cholestasis of pregnancy (ICP) in patients presenting to a tertiary care hospital. Study Design: Case control study. Place and Duration of Study: Department of Gynaecology and Obstetrics, Pakistan Naval Ship Shifa Hospital Karachi, from Jan to Dec 2019. Methodology: All pregnant women with symptoms of intrahepatic cholestasis of pregnancy confirmed on history, examination and investigations were included. A comparison cohort of pregnant women with neither hepatobiliary nor medical illness associated with pregnancy was selected. Comparison of risk factors was done between both the groups. Results: Out of 6932 obstetric patients, 90 (1.29%) had intrahepatic cholestasis of pregnancy. Pruritis was cardinal symptoms in all (100%) the patients followed by excoriation marks (75.55%). Intrahepatic cholestasis of pregnancy was significantly found in women with multiple pregnancy (OR=1.81; 95% CI 0.51-6.42), antecedent intrahepatic cholestasis of pregnancy (OR=36.81; 95% CI 8.53-158.79), family history of intrahepatic cholestasis of pregnancy (OR=17.80; 95% CI 2.29-137.91) and history of pruritis with obstetric cholestasis of pregnancy use (OR=16.25; 95% CI 0.91-289.08). Conclusion: Intrahepatic cholestasis of pregnancy was observed in less than two percent cases. Risk of intrahepatic cholestasis of pregnancy was found to be increased with multiple pregnancies, antecedent intrahepatic cholestasis of pregnancy, family history of intrahepatic cholestasis of pregnancy and history of pruritis with prior obstetric cholestasis of pregnancy use.
format	article
author	Rabiah Anwar Kashif Razzaq Aysha Shahid Afeera Afsheen Amera Tariq Irum Saleem
author_facet	Rabiah Anwar Kashif Razzaq Aysha Shahid Afeera Afsheen Amera Tariq Irum Saleem
author_sort	Rabiah Anwar
title	EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE
title_short	EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE
title_full	EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE
title_fullStr	EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE
title_full_unstemmed	EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE
title_sort	evaluation of risk factors for intrahepatic cholestasis of pregnancy in patients presenting to a tertiary care centre
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/f9287f355ea04c04960c5c75ddaf3c67
work_keys_str_mv	AT rabiahanwar evaluationofriskfactorsforintrahepaticcholestasisofpregnancyinpatientspresentingtoatertiarycarecentre AT kashifrazzaq evaluationofriskfactorsforintrahepaticcholestasisofpregnancyinpatientspresentingtoatertiarycarecentre AT ayshashahid evaluationofriskfactorsforintrahepaticcholestasisofpregnancyinpatientspresentingtoatertiarycarecentre AT afeeraafsheen evaluationofriskfactorsforintrahepaticcholestasisofpregnancyinpatientspresentingtoatertiarycarecentre AT ameratariq evaluationofriskfactorsforintrahepaticcholestasisofpregnancyinpatientspresentingtoatertiarycarecentre AT irumsaleem evaluationofriskfactorsforintrahepaticcholestasisofpregnancyinpatientspresentingtoatertiarycarecentre
_version_	1718415954255282176

EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE

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