Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

The mechanisms underlying the spreading of α-synuclein in various α-synucleinopathies are unclear. Here, the authors show that targeting the TLR2/MyD88/NF-κB pathway can reduce α-synuclein spreading, reduce neuroinflammation, and protect dopaminergic neurons in vitro and in mouse models

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Autores principales:	Debashis Dutta, Malabendu Jana, Moumita Majumder, Susanta Mondal, Avik Roy, Kalipada Pahan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f92aee678ddc40cc8438a928b0305322
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spelling	oai:doaj.org-article:f92aee678ddc40cc8438a928b03053222021-12-02T17:42:05ZSelective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo10.1038/s41467-021-25767-12041-1723https://doaj.org/article/f92aee678ddc40cc8438a928b03053222021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25767-1https://doaj.org/toc/2041-1723The mechanisms underlying the spreading of α-synuclein in various α-synucleinopathies are unclear. Here, the authors show that targeting the TLR2/MyD88/NF-κB pathway can reduce α-synuclein spreading, reduce neuroinflammation, and protect dopaminergic neurons in vitro and in mouse modelsDebashis DuttaMalabendu JanaMoumita MajumderSusanta MondalAvik RoyKalipada PahanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Debashis Dutta Malabendu Jana Moumita Majumder Susanta Mondal Avik Roy Kalipada Pahan Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
description	The mechanisms underlying the spreading of α-synuclein in various α-synucleinopathies are unclear. Here, the authors show that targeting the TLR2/MyD88/NF-κB pathway can reduce α-synuclein spreading, reduce neuroinflammation, and protect dopaminergic neurons in vitro and in mouse models
format	article
author	Debashis Dutta Malabendu Jana Moumita Majumder Susanta Mondal Avik Roy Kalipada Pahan
author_facet	Debashis Dutta Malabendu Jana Moumita Majumder Susanta Mondal Avik Roy Kalipada Pahan
author_sort	Debashis Dutta
title	Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
title_short	Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
title_full	Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
title_fullStr	Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
title_full_unstemmed	Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
title_sort	selective targeting of the tlr2/myd88/nf-κb pathway reduces α-synuclein spreading in vitro and in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f92aee678ddc40cc8438a928b0305322
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Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

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