Bone remodeling in women with diabetes mellitus

Background. 1t is known that the type 2 diabetes mellitus (DM) and osteoporosis are more often diagnosed in senior women. The condition of a bone tissue is accompanied by the metabolic violations that are typical for DM. The recent researches established the multidirectional changes of bone remodeli...

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Autores principales:	T. P. Bardymova, M. V. Mistyakov, Y. A. Basharina, E. B. Minaeva, A. S. Abzaeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	diabetes mellitus osteoporosis insufficiency/deficiency of vitamin d Science Q
Acceso en línea:	https://doaj.org/article/f92b1b05964a41b294edd1b76c3d97f2
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spelling	oai:doaj.org-article:f92b1b05964a41b294edd1b76c3d97f22021-11-23T06:14:38ZBone remodeling in women with diabetes mellitus2541-94202587-959610.12737/article_5a3a0d8f913509.24544012https://doaj.org/article/f92b1b05964a41b294edd1b76c3d97f22017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/503https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. 1t is known that the type 2 diabetes mellitus (DM) and osteoporosis are more often diagnosed in senior women. The condition of a bone tissue is accompanied by the metabolic violations that are typical for DM. The recent researches established the multidirectional changes of bone remodeling markers in women with type 2 DM at different age periods. Aims: to study the condition of bone remodeling in women with type 2 DM at different age periods. Materials and methods. We examined 27 women with type 2 DM, among them 15 were in the post-menopausal period and 12 with preserved menstrual function. Levels of osteocalcin, N-terminal propeptide of type 1 collagen (P1NP), C-terminal telopeptide of type 1 collagen (β-Crosslaps), 25-OH vitamin D, the ionized calcium were researched. Results. The analysis showed that increase in β-Crosslaps levels, P1NP, levels of osteocaltcin were observed in women with type 2 DM in the post-menopausal period, compared to parameters of women with type 2 DM with preserved menstrual function. Inverse correlation relation of osteocaltcin and 25-OH vitamin D was revealed in women with type 2 DM. Conclusion. Significant increase in markers of osteosynthesis and osteoresorption in women with type 2 DM was shown in the post-menopausal period compared with indicators of women with type 2 DM with preserved menstrual function.T. P. BardymovaM. V. MistyakovY. A. BasharinaE. B. MinaevaA. S. AbzaevaScientific Сentre for Family Health and Human Reproduction Problemsarticlediabetes mellitusosteoporosisinsufficiency/deficiency of vitamin dScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(2), Pp 33-36 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	diabetes mellitus osteoporosis insufficiency/deficiency of vitamin d Science Q
spellingShingle	diabetes mellitus osteoporosis insufficiency/deficiency of vitamin d Science Q T. P. Bardymova M. V. Mistyakov Y. A. Basharina E. B. Minaeva A. S. Abzaeva Bone remodeling in women with diabetes mellitus
description	Background. 1t is known that the type 2 diabetes mellitus (DM) and osteoporosis are more often diagnosed in senior women. The condition of a bone tissue is accompanied by the metabolic violations that are typical for DM. The recent researches established the multidirectional changes of bone remodeling markers in women with type 2 DM at different age periods. Aims: to study the condition of bone remodeling in women with type 2 DM at different age periods. Materials and methods. We examined 27 women with type 2 DM, among them 15 were in the post-menopausal period and 12 with preserved menstrual function. Levels of osteocalcin, N-terminal propeptide of type 1 collagen (P1NP), C-terminal telopeptide of type 1 collagen (β-Crosslaps), 25-OH vitamin D, the ionized calcium were researched. Results. The analysis showed that increase in β-Crosslaps levels, P1NP, levels of osteocaltcin were observed in women with type 2 DM in the post-menopausal period, compared to parameters of women with type 2 DM with preserved menstrual function. Inverse correlation relation of osteocaltcin and 25-OH vitamin D was revealed in women with type 2 DM. Conclusion. Significant increase in markers of osteosynthesis and osteoresorption in women with type 2 DM was shown in the post-menopausal period compared with indicators of women with type 2 DM with preserved menstrual function.
format	article
author	T. P. Bardymova M. V. Mistyakov Y. A. Basharina E. B. Minaeva A. S. Abzaeva
author_facet	T. P. Bardymova M. V. Mistyakov Y. A. Basharina E. B. Minaeva A. S. Abzaeva
author_sort	T. P. Bardymova
title	Bone remodeling in women with diabetes mellitus
title_short	Bone remodeling in women with diabetes mellitus
title_full	Bone remodeling in women with diabetes mellitus
title_fullStr	Bone remodeling in women with diabetes mellitus
title_full_unstemmed	Bone remodeling in women with diabetes mellitus
title_sort	bone remodeling in women with diabetes mellitus
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/f92b1b05964a41b294edd1b76c3d97f2
work_keys_str_mv	AT tpbardymova boneremodelinginwomenwithdiabetesmellitus AT mvmistyakov boneremodelinginwomenwithdiabetesmellitus AT yabasharina boneremodelinginwomenwithdiabetesmellitus AT ebminaeva boneremodelinginwomenwithdiabetesmellitus AT asabzaeva boneremodelinginwomenwithdiabetesmellitus
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Bone remodeling in women with diabetes mellitus

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