Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis

Checkpoint blocking therapies are used to treat metastatic melanoma, but can have adverse immune-mediated effects, including liver pathology. Here the authors identify an expanded pool of CD4+ effector memory T cells resulting from prior CMV exposure as a risk factor for this adverse effect in these...

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Autores principales:	James A. Hutchinson, Katharina Kronenberg, Paloma Riquelme, Jürgen J. Wenzel, Gunther Glehr, Hannah-Lou Schilling, Florian Zeman, Katja Evert, Martin Schmiedel, Marion Mickler, Konstantin Drexler, Florian Bitterer, Laura Cordero, Lukas Beyer, Christian Bach, Josef Koestler, Ralph Burkhardt, Hans J. Schlitt, Dirk Hellwig, Jens M. Werner, Rainer Spang, Barbara Schmidt, Edward K. Geissler, Sebastian Haferkamp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f92b658607e1458c8aa40adb3861c519
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spelling	oai:doaj.org-article:f92b658607e1458c8aa40adb3861c5192021-12-02T13:33:01ZVirus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis10.1038/s41467-021-21572-y2041-1723https://doaj.org/article/f92b658607e1458c8aa40adb3861c5192021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21572-yhttps://doaj.org/toc/2041-1723Checkpoint blocking therapies are used to treat metastatic melanoma, but can have adverse immune-mediated effects, including liver pathology. Here the authors identify an expanded pool of CD4+ effector memory T cells resulting from prior CMV exposure as a risk factor for this adverse effect in these patients.James A. HutchinsonKatharina KronenbergPaloma RiquelmeJürgen J. WenzelGunther GlehrHannah-Lou SchillingFlorian ZemanKatja EvertMartin SchmiedelMarion MicklerKonstantin DrexlerFlorian BittererLaura CorderoLukas BeyerChristian BachJosef KoestlerRalph BurkhardtHans J. SchlittDirk HellwigJens M. WernerRainer SpangBarbara SchmidtEdward K. GeisslerSebastian HaferkampNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James A. Hutchinson Katharina Kronenberg Paloma Riquelme Jürgen J. Wenzel Gunther Glehr Hannah-Lou Schilling Florian Zeman Katja Evert Martin Schmiedel Marion Mickler Konstantin Drexler Florian Bitterer Laura Cordero Lukas Beyer Christian Bach Josef Koestler Ralph Burkhardt Hans J. Schlitt Dirk Hellwig Jens M. Werner Rainer Spang Barbara Schmidt Edward K. Geissler Sebastian Haferkamp Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
description	Checkpoint blocking therapies are used to treat metastatic melanoma, but can have adverse immune-mediated effects, including liver pathology. Here the authors identify an expanded pool of CD4+ effector memory T cells resulting from prior CMV exposure as a risk factor for this adverse effect in these patients.
format	article
author	James A. Hutchinson Katharina Kronenberg Paloma Riquelme Jürgen J. Wenzel Gunther Glehr Hannah-Lou Schilling Florian Zeman Katja Evert Martin Schmiedel Marion Mickler Konstantin Drexler Florian Bitterer Laura Cordero Lukas Beyer Christian Bach Josef Koestler Ralph Burkhardt Hans J. Schlitt Dirk Hellwig Jens M. Werner Rainer Spang Barbara Schmidt Edward K. Geissler Sebastian Haferkamp
author_facet	James A. Hutchinson Katharina Kronenberg Paloma Riquelme Jürgen J. Wenzel Gunther Glehr Hannah-Lou Schilling Florian Zeman Katja Evert Martin Schmiedel Marion Mickler Konstantin Drexler Florian Bitterer Laura Cordero Lukas Beyer Christian Bach Josef Koestler Ralph Burkhardt Hans J. Schlitt Dirk Hellwig Jens M. Werner Rainer Spang Barbara Schmidt Edward K. Geissler Sebastian Haferkamp
author_sort	James A. Hutchinson
title	Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
title_short	Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
title_full	Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
title_fullStr	Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
title_full_unstemmed	Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
title_sort	virus-specific memory t cell responses unmasked by immune checkpoint blockade cause hepatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f92b658607e1458c8aa40adb3861c519
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Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis

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