Human miRNA precursors with box H/ACA snoRNA features.

MicroRNAs (miRNAs) and small nucleolar RNAs (snoRNAs) are two classes of small non-coding regulatory RNAs, which have been much investigated in recent years. While their respective functions in the cell are distinct, they share interesting genomic similarities, and recent sequencing projects have id...

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Autores principales:	Michelle S Scott, Fabio Avolio, Motoharu Ono, Angus I Lamond, Geoffrey J Barton
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f92bc17325f64b24b331257419185282
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spelling	oai:doaj.org-article:f92bc17325f64b24b3312574191852822021-11-25T05:42:10ZHuman miRNA precursors with box H/ACA snoRNA features.1553-734X1553-735810.1371/journal.pcbi.1000507https://doaj.org/article/f92bc17325f64b24b3312574191852822009-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19763159/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358MicroRNAs (miRNAs) and small nucleolar RNAs (snoRNAs) are two classes of small non-coding regulatory RNAs, which have been much investigated in recent years. While their respective functions in the cell are distinct, they share interesting genomic similarities, and recent sequencing projects have identified processed forms of snoRNAs that resemble miRNAs. Here, we investigate a possible evolutionary relationship between miRNAs and box H/ACA snoRNAs. A comparison of the genomic locations of reported miRNAs and snoRNAs reveals an overlap of specific members of these classes. To test the hypothesis that some miRNAs might have evolved from snoRNA encoding genomic regions, reported miRNA-encoding regions were scanned for the presence of box H/ACA snoRNA features. Twenty miRNA precursors show significant similarity to H/ACA snoRNAs as predicted by snoGPS. These include molecules predicted to target known ribosomal RNA pseudouridylation sites in vivo for which no guide snoRNA has yet been reported. The predicted folded structures of these twenty H/ACA snoRNA-like miRNA precursors reveal molecules which resemble the structures of known box H/ACA snoRNAs. The genomic regions surrounding these predicted snoRNA-like miRNAs are often similar to regions around snoRNA retroposons, including the presence of transposable elements, target site duplications and poly (A) tails. We further show that the precursors of five H/ACA snoRNA-like miRNAs (miR-151, miR-605, mir-664, miR-215 and miR-140) bind to dyskerin, a specific protein component of functional box H/ACA small nucleolar ribonucleoprotein complexes suggesting that these molecules have retained some H/ACA snoRNA functionality. The detection of small RNA molecules that share features of miRNAs and snoRNAs suggest that these classes of RNA may have an evolutionary relationship.Michelle S ScottFabio AvolioMotoharu OnoAngus I LamondGeoffrey J BartonPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 5, Iss 9, p e1000507 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Michelle S Scott Fabio Avolio Motoharu Ono Angus I Lamond Geoffrey J Barton Human miRNA precursors with box H/ACA snoRNA features.
description	MicroRNAs (miRNAs) and small nucleolar RNAs (snoRNAs) are two classes of small non-coding regulatory RNAs, which have been much investigated in recent years. While their respective functions in the cell are distinct, they share interesting genomic similarities, and recent sequencing projects have identified processed forms of snoRNAs that resemble miRNAs. Here, we investigate a possible evolutionary relationship between miRNAs and box H/ACA snoRNAs. A comparison of the genomic locations of reported miRNAs and snoRNAs reveals an overlap of specific members of these classes. To test the hypothesis that some miRNAs might have evolved from snoRNA encoding genomic regions, reported miRNA-encoding regions were scanned for the presence of box H/ACA snoRNA features. Twenty miRNA precursors show significant similarity to H/ACA snoRNAs as predicted by snoGPS. These include molecules predicted to target known ribosomal RNA pseudouridylation sites in vivo for which no guide snoRNA has yet been reported. The predicted folded structures of these twenty H/ACA snoRNA-like miRNA precursors reveal molecules which resemble the structures of known box H/ACA snoRNAs. The genomic regions surrounding these predicted snoRNA-like miRNAs are often similar to regions around snoRNA retroposons, including the presence of transposable elements, target site duplications and poly (A) tails. We further show that the precursors of five H/ACA snoRNA-like miRNAs (miR-151, miR-605, mir-664, miR-215 and miR-140) bind to dyskerin, a specific protein component of functional box H/ACA small nucleolar ribonucleoprotein complexes suggesting that these molecules have retained some H/ACA snoRNA functionality. The detection of small RNA molecules that share features of miRNAs and snoRNAs suggest that these classes of RNA may have an evolutionary relationship.
format	article
author	Michelle S Scott Fabio Avolio Motoharu Ono Angus I Lamond Geoffrey J Barton
author_facet	Michelle S Scott Fabio Avolio Motoharu Ono Angus I Lamond Geoffrey J Barton
author_sort	Michelle S Scott
title	Human miRNA precursors with box H/ACA snoRNA features.
title_short	Human miRNA precursors with box H/ACA snoRNA features.
title_full	Human miRNA precursors with box H/ACA snoRNA features.
title_fullStr	Human miRNA precursors with box H/ACA snoRNA features.
title_full_unstemmed	Human miRNA precursors with box H/ACA snoRNA features.
title_sort	human mirna precursors with box h/aca snorna features.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/f92bc17325f64b24b331257419185282
work_keys_str_mv	AT michellesscott humanmirnaprecursorswithboxhacasnornafeatures AT fabioavolio humanmirnaprecursorswithboxhacasnornafeatures AT motoharuono humanmirnaprecursorswithboxhacasnornafeatures AT angusilamond humanmirnaprecursorswithboxhacasnornafeatures AT geoffreyjbarton humanmirnaprecursorswithboxhacasnornafeatures
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Human miRNA precursors with box H/ACA snoRNA features.

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