Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

Oncogenic RAS mutants are key anti-cancer targets as KRas mutations are very frequent in human cancers. Here, the authors engineer a cytosol-penetrating anti-Ras antibody and demonstrate its ability to block RAS-effector protein interactions inhibiting tumour growth of Ras mutant-driven cancers.

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Autores principales:	Seung-Min Shin, Dong-Ki Choi, Keunok Jung, Jeomil Bae, Ji-sun Kim, Seong-wook Park, Ki-Hoon Song, Yong-Sung Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f92bfa18577140acbe2a6429590c88a9
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spelling	oai:doaj.org-article:f92bfa18577140acbe2a6429590c88a92021-12-02T14:40:33ZAntibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration10.1038/ncomms150902041-1723https://doaj.org/article/f92bfa18577140acbe2a6429590c88a92017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15090https://doaj.org/toc/2041-1723Oncogenic RAS mutants are key anti-cancer targets as KRas mutations are very frequent in human cancers. Here, the authors engineer a cytosol-penetrating anti-Ras antibody and demonstrate its ability to block RAS-effector protein interactions inhibiting tumour growth of Ras mutant-driven cancers.Seung-Min ShinDong-Ki ChoiKeunok JungJeomil BaeJi-sun KimSeong-wook ParkKi-Hoon SongYong-Sung KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seung-Min Shin Dong-Ki Choi Keunok Jung Jeomil Bae Ji-sun Kim Seong-wook Park Ki-Hoon Song Yong-Sung Kim Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration
description	Oncogenic RAS mutants are key anti-cancer targets as KRas mutations are very frequent in human cancers. Here, the authors engineer a cytosol-penetrating anti-Ras antibody and demonstrate its ability to block RAS-effector protein interactions inhibiting tumour growth of Ras mutant-driven cancers.
format	article
author	Seung-Min Shin Dong-Ki Choi Keunok Jung Jeomil Bae Ji-sun Kim Seong-wook Park Ki-Hoon Song Yong-Sung Kim
author_facet	Seung-Min Shin Dong-Ki Choi Keunok Jung Jeomil Bae Ji-sun Kim Seong-wook Park Ki-Hoon Song Yong-Sung Kim
author_sort	Seung-Min Shin
title	Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration
title_short	Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration
title_full	Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration
title_fullStr	Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration
title_full_unstemmed	Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration
title_sort	antibody targeting intracellular oncogenic ras mutants exerts anti-tumour effects after systemic administration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f92bfa18577140acbe2a6429590c88a9
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Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

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