The oncological relevance of fragile sites in cancer

In this Perspective, Simpson, Pye, and Whitaker discuss recent research identifying structural genomic variants in human cancers with a particular focus on deletions and duplications at genomic fragile sites. They argue that tumours with predominantly fragile site structural variants represent a dis...

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Autores principales:	Benjamin S. Simpson, Hayley Pye, Hayley C. Whitaker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f92db571ff224759973b72f56540a4ab
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spelling	oai:doaj.org-article:f92db571ff224759973b72f56540a4ab2021-12-02T15:55:21ZThe oncological relevance of fragile sites in cancer10.1038/s42003-021-02020-52399-3642https://doaj.org/article/f92db571ff224759973b72f56540a4ab2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02020-5https://doaj.org/toc/2399-3642In this Perspective, Simpson, Pye, and Whitaker discuss recent research identifying structural genomic variants in human cancers with a particular focus on deletions and duplications at genomic fragile sites. They argue that tumours with predominantly fragile site structural variants represent a distinct mutational signature that warrants further research.Benjamin S. SimpsonHayley PyeHayley C. WhitakerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Benjamin S. Simpson Hayley Pye Hayley C. Whitaker The oncological relevance of fragile sites in cancer
description	In this Perspective, Simpson, Pye, and Whitaker discuss recent research identifying structural genomic variants in human cancers with a particular focus on deletions and duplications at genomic fragile sites. They argue that tumours with predominantly fragile site structural variants represent a distinct mutational signature that warrants further research.
format	article
author	Benjamin S. Simpson Hayley Pye Hayley C. Whitaker
author_facet	Benjamin S. Simpson Hayley Pye Hayley C. Whitaker
author_sort	Benjamin S. Simpson
title	The oncological relevance of fragile sites in cancer
title_short	The oncological relevance of fragile sites in cancer
title_full	The oncological relevance of fragile sites in cancer
title_fullStr	The oncological relevance of fragile sites in cancer
title_full_unstemmed	The oncological relevance of fragile sites in cancer
title_sort	oncological relevance of fragile sites in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f92db571ff224759973b72f56540a4ab
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The oncological relevance of fragile sites in cancer

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