Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.

Plasmodium vivax is considered to be rare in the predominantly Duffy negative populations of Sub-Saharan Africa, as this red blood cell surface antigen is essential for invasion by the parasite. However, despite only very few reports of molecularly confirmed P. vivax from tropical Africa, serologica...

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Autores principales:	Mehul Dhorda, Dan Nyehangane, Laurent Rénia, Patrice Piola, Philippe J Guerin, Georges Snounou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f92ff0b66af941c9a667f3f5e530b331
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spelling	oai:doaj.org-article:f92ff0b66af941c9a667f3f5e530b3312021-11-18T06:53:59ZTransmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.1932-620310.1371/journal.pone.0019801https://doaj.org/article/f92ff0b66af941c9a667f3f5e530b3312011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21603649/?tool=EBIhttps://doaj.org/toc/1932-6203Plasmodium vivax is considered to be rare in the predominantly Duffy negative populations of Sub-Saharan Africa, as this red blood cell surface antigen is essential for invasion by the parasite. However, despite only very few reports of molecularly confirmed P. vivax from tropical Africa, serological evidence indicated that 13% of the persons sampled in Congo had been exposed to P. vivax. We identified P. vivax by microscopy in 8 smears from Ugandan pregnant women who had been enrolled in a longitudinal study of malaria in pregnancy. A nested polymerase chain reaction (PCR) protocol was used to detect and identify the Plasmodium parasites present. PCR analysis confirmed the presence of P. vivax for three of the women and analysis of all available samples from these women revealed clinically silent chronic low-grade vivax infections for two of them. The parasites in one woman carried pyrimethamine resistance-associated double non-synonymous mutations in the P. vivax dihydrofolate reductase gene. The three women found infected with P. vivax were Duffy positive as were nine of 68 women randomly selected from the cohort. The data presented from these three case reports is consistent with stable transmission of malaria in a predominantly Duffy negative African population. Given the substantial morbidity associated with vivax infection in non-African endemic areas, it will be important to investigate whether the distribution and prevalence of P. vivax have been underestimated in Sub-Saharan Africa. This is particularly important in the context of the drive to eliminate malaria and its morbidity.Mehul DhordaDan NyehanganeLaurent RéniaPatrice PiolaPhilippe J GuerinGeorges SnounouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19801 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mehul Dhorda Dan Nyehangane Laurent Rénia Patrice Piola Philippe J Guerin Georges Snounou Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.
description	Plasmodium vivax is considered to be rare in the predominantly Duffy negative populations of Sub-Saharan Africa, as this red blood cell surface antigen is essential for invasion by the parasite. However, despite only very few reports of molecularly confirmed P. vivax from tropical Africa, serological evidence indicated that 13% of the persons sampled in Congo had been exposed to P. vivax. We identified P. vivax by microscopy in 8 smears from Ugandan pregnant women who had been enrolled in a longitudinal study of malaria in pregnancy. A nested polymerase chain reaction (PCR) protocol was used to detect and identify the Plasmodium parasites present. PCR analysis confirmed the presence of P. vivax for three of the women and analysis of all available samples from these women revealed clinically silent chronic low-grade vivax infections for two of them. The parasites in one woman carried pyrimethamine resistance-associated double non-synonymous mutations in the P. vivax dihydrofolate reductase gene. The three women found infected with P. vivax were Duffy positive as were nine of 68 women randomly selected from the cohort. The data presented from these three case reports is consistent with stable transmission of malaria in a predominantly Duffy negative African population. Given the substantial morbidity associated with vivax infection in non-African endemic areas, it will be important to investigate whether the distribution and prevalence of P. vivax have been underestimated in Sub-Saharan Africa. This is particularly important in the context of the drive to eliminate malaria and its morbidity.
format	article
author	Mehul Dhorda Dan Nyehangane Laurent Rénia Patrice Piola Philippe J Guerin Georges Snounou
author_facet	Mehul Dhorda Dan Nyehangane Laurent Rénia Patrice Piola Philippe J Guerin Georges Snounou
author_sort	Mehul Dhorda
title	Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.
title_short	Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.
title_full	Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.
title_fullStr	Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.
title_full_unstemmed	Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.
title_sort	transmission of plasmodium vivax in south-western uganda: report of three cases in pregnant women.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/f92ff0b66af941c9a667f3f5e530b331
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Transmission of Plasmodium vivax in south-western Uganda: report of three cases in pregnant women.

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