A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires

A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires

Common approaches for monitoring T cell responses are limited in their multiplexity and sensitivity. In contrast, deep sequencing of the T Cell Receptor (TCR) repertoire provides a global view that is limited only in terms of theoretical sensitivity due to the depth of available sampling; however, t...

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Bibliographic Details
Main Authors: Valentina Ceglia, Erin J. Kelley, Annalee S. Boyle, Sandra Zurawski, Heather L. Mead, Caroline E. Harms, Jean-Philippe Blanck, Anne-Laure Flamar, Jung Hwa Kirschman, Paul Ogongo, Joel D. Ernst, Yves Levy, Gerard Zurawski, John A. Altin
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
T cell receptor (TCR)
T cell responses
vaccines
dendritic cells
monoclonal antibodies
TCR sequencing
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/f93445a02b2b471c835e0f59d1527059
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https://doaj.org/article/f93445a02b2b471c835e0f59d1527059

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