Whole Cow’s Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults
Background: Lactose intolerance is the most frequent food intolerance, but many subjects with self-reported milk intolerance (SRMI) are asymptomatic at lactose hydrogen breath test (LHBT). The aim of this study was to evaluate the frequency of lactose intolerance in SRMI patients and their clinical...
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MDPI AG
2021
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oai:doaj.org-article:f93606ab8a93421ba33a09ea370a463f2021-11-25T18:34:31ZWhole Cow’s Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults10.3390/nu131138332072-6643https://doaj.org/article/f93606ab8a93421ba33a09ea370a463f2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3833https://doaj.org/toc/2072-6643Background: Lactose intolerance is the most frequent food intolerance, but many subjects with self-reported milk intolerance (SRMI) are asymptomatic at lactose hydrogen breath test (LHBT). The aim of this study was to evaluate the frequency of lactose intolerance in SRMI patients and their clinical characteristics. Methods: In a retrospective study, the clinical records of 314 SRMI patients (259 females, mean age: 39.1 ± 13.5 years) were reviewed; 102 patients with irritable bowel syndrome (IBS) served as controls. In a prospective study, 42 SRMI patients, negatives at the LHBT, underwent a double-blind, placebo-controlled (DBPC) whole cow’s milk challenge. Results: In the retrospective study, only 178 patients (56%) were lactose maldigesters and intolerant at LHBT; 68% of the subjects with SRMI were suffering from IBS; 74% reported dyspepsia (<i>p</i> = 0.0001 vs. IBS controls); and weight loss was recorded in 62 SRMI patients (20%) (<i>p</i> = 0.01 vs. IBS controls). Duodenal histology showed intra-epithelial lymphocytosis in about 60% of cases. In the prospective study, 36 patients (86%) experienced symptoms during the DBPC cow’s milk challenge, and only 4 patients (9%) reacted to placebo (<i>p</i> = 0.0001). Conclusions: A percentage of SRMI patients were not suffering from lactose intolerance. DBPC revealed that SRMI patients had clinical reactions when exposed to whole cow’s milk.Antonio CarroccioMaurizio SoresiBeatrice MantiaFrancesca FayerFrancesco La BlascaAurelio SeiditaAlberto D’AlcamoAda Maria FlorenaChiara TinèChiara GarlisiPasquale MansuetoMDPI AGarticleself-reported milk intolerancelactose intolerancelactose hydrogen breath testcow’s milk protein allergyIBSHLANutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3833, p 3833 (2021) |
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| collection |
DOAJ |
| language |
EN |
| topic |
self-reported milk intolerance lactose intolerance lactose hydrogen breath test cow’s milk protein allergy IBS HLA Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
self-reported milk intolerance lactose intolerance lactose hydrogen breath test cow’s milk protein allergy IBS HLA Nutrition. Foods and food supply TX341-641 Antonio Carroccio Maurizio Soresi Beatrice Mantia Francesca Fayer Francesco La Blasca Aurelio Seidita Alberto D’Alcamo Ada Maria Florena Chiara Tinè Chiara Garlisi Pasquale Mansueto Whole Cow’s Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults |
| description |
Background: Lactose intolerance is the most frequent food intolerance, but many subjects with self-reported milk intolerance (SRMI) are asymptomatic at lactose hydrogen breath test (LHBT). The aim of this study was to evaluate the frequency of lactose intolerance in SRMI patients and their clinical characteristics. Methods: In a retrospective study, the clinical records of 314 SRMI patients (259 females, mean age: 39.1 ± 13.5 years) were reviewed; 102 patients with irritable bowel syndrome (IBS) served as controls. In a prospective study, 42 SRMI patients, negatives at the LHBT, underwent a double-blind, placebo-controlled (DBPC) whole cow’s milk challenge. Results: In the retrospective study, only 178 patients (56%) were lactose maldigesters and intolerant at LHBT; 68% of the subjects with SRMI were suffering from IBS; 74% reported dyspepsia (<i>p</i> = 0.0001 vs. IBS controls); and weight loss was recorded in 62 SRMI patients (20%) (<i>p</i> = 0.01 vs. IBS controls). Duodenal histology showed intra-epithelial lymphocytosis in about 60% of cases. In the prospective study, 36 patients (86%) experienced symptoms during the DBPC cow’s milk challenge, and only 4 patients (9%) reacted to placebo (<i>p</i> = 0.0001). Conclusions: A percentage of SRMI patients were not suffering from lactose intolerance. DBPC revealed that SRMI patients had clinical reactions when exposed to whole cow’s milk. |
| format |
article |
| author |
Antonio Carroccio Maurizio Soresi Beatrice Mantia Francesca Fayer Francesco La Blasca Aurelio Seidita Alberto D’Alcamo Ada Maria Florena Chiara Tinè Chiara Garlisi Pasquale Mansueto |
| author_facet |
Antonio Carroccio Maurizio Soresi Beatrice Mantia Francesca Fayer Francesco La Blasca Aurelio Seidita Alberto D’Alcamo Ada Maria Florena Chiara Tinè Chiara Garlisi Pasquale Mansueto |
| author_sort |
Antonio Carroccio |
| title |
Whole Cow’s Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults |
| title_short |
Whole Cow’s Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults |
| title_full |
Whole Cow’s Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults |
| title_fullStr |
Whole Cow’s Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults |
| title_full_unstemmed |
Whole Cow’s Milk but Not Lactose Can Induce Symptoms inPatients with Self-Reported Milk Intolerance: Evidence of Cow’s Milk Sensitivity in Adults |
| title_sort |
whole cow’s milk but not lactose can induce symptoms inpatients with self-reported milk intolerance: evidence of cow’s milk sensitivity in adults |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/f93606ab8a93421ba33a09ea370a463f |
| work_keys_str_mv |
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