Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity

The conserved SAM motif of Polycomb Repressive Complex 1 subunit Ph has been shown to play an important role in chromatin organization. Here, the authors study the effect of Ph SAM on chromatin in vitro, showing that it induces the formation of concentrated, phase-separated condensates, which enhanc...

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Autores principales:	Elias Seif, Jin Joo Kang, Charles Sasseville, Olga Senkovich, Alexander Kaltashov, Elodie L. Boulier, Ibani Kapur, Chongwoo A. Kim, Nicole J. Francis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f93773e13b25400184a9e8d15645342f
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spelling	oai:doaj.org-article:f93773e13b25400184a9e8d15645342f2021-12-02T14:40:51ZPhase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity10.1038/s41467-020-19435-z2041-1723https://doaj.org/article/f93773e13b25400184a9e8d15645342f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19435-zhttps://doaj.org/toc/2041-1723The conserved SAM motif of Polycomb Repressive Complex 1 subunit Ph has been shown to play an important role in chromatin organization. Here, the authors study the effect of Ph SAM on chromatin in vitro, showing that it induces the formation of concentrated, phase-separated condensates, which enhance the ubiquitin ligase activity of PRC1.Elias SeifJin Joo KangCharles SassevilleOlga SenkovichAlexander KaltashovElodie L. BoulierIbani KapurChongwoo A. KimNicole J. FrancisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elias Seif Jin Joo Kang Charles Sasseville Olga Senkovich Alexander Kaltashov Elodie L. Boulier Ibani Kapur Chongwoo A. Kim Nicole J. Francis Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
description	The conserved SAM motif of Polycomb Repressive Complex 1 subunit Ph has been shown to play an important role in chromatin organization. Here, the authors study the effect of Ph SAM on chromatin in vitro, showing that it induces the formation of concentrated, phase-separated condensates, which enhance the ubiquitin ligase activity of PRC1.
format	article
author	Elias Seif Jin Joo Kang Charles Sasseville Olga Senkovich Alexander Kaltashov Elodie L. Boulier Ibani Kapur Chongwoo A. Kim Nicole J. Francis
author_facet	Elias Seif Jin Joo Kang Charles Sasseville Olga Senkovich Alexander Kaltashov Elodie L. Boulier Ibani Kapur Chongwoo A. Kim Nicole J. Francis
author_sort	Elias Seif
title	Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
title_short	Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
title_full	Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
title_fullStr	Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
title_full_unstemmed	Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
title_sort	phase separation by the polyhomeotic sterile alpha motif compartmentalizes polycomb group proteins and enhances their activity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f93773e13b25400184a9e8d15645342f
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Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity

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