Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review

Martina Votto,1,2,* Maria De Filippo,1,2,* Amelia Licari,1,2 Alessia Marseglia,2 Mara De Amici,3 Gian Luigi Marseglia1,2 1Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy;...

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Autores principales:	Votto M, De Filippo M, Licari A, Marseglia A, De Amici M, Marseglia GL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	severe asthma children adolescents biological therapy endotype phenotype. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f937ff8b73ab4825868d273091a4c945
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spelling	oai:doaj.org-article:f937ff8b73ab4825868d273091a4c9452021-12-02T14:28:52ZBiological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review1177-5491https://doaj.org/article/f937ff8b73ab4825868d273091a4c9452021-05-01T00:00:00Zhttps://www.dovepress.com/biological-therapies-in-children-and-adolescents-with-severe-uncontrol-peer-reviewed-fulltext-article-BTThttps://doaj.org/toc/1177-5491Martina Votto,1,2,* Maria De Filippo,1,2,* Amelia Licari,1,2 Alessia Marseglia,2 Mara De Amici,3 Gian Luigi Marseglia1,2 1Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; 3Immuno-Allergology Laboratory, Clinical Chemistry Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy*These authors contributed equally to this workCorrespondence: Amelia LicariPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, p.le C. Golgi n.19, Pavia, 27100, ItalyTel/Fax +390382502629Email amelia.licari@unipv.itAbstract: Severe uncontrolled asthma is a complex and heterogeneous disease. A multidisciplinary assessment is required to correctly identify and manage children and adolescents with severe asthma because they may require strict monitoring and additional treatment with advanced targeted therapies. Recent research efforts have focused on identifying epidemiologic, clinical, and molecular mechanisms that underlie severe asthma, leading to the recognition of different phenotypes and endotypes and identifying biomarkers able to predict the response to biologic therapies. Additional progress has occurred by introducing biological therapies that have revolutionized the care of chronic allergic diseases in the adult and pediatric population. In this review, we briefly summarized the current literature on biological therapies to treat severe asthma in children and adolescents.Keywords: severe asthma, children, adolescents, biological therapy, endotype, phenotypeVotto MDe Filippo MLicari AMarseglia ADe Amici MMarseglia GLDove Medical Pressarticlesevere asthmachildrenadolescentsbiological therapyendotypephenotype.Medicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 15, Pp 133-142 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	severe asthma children adolescents biological therapy endotype phenotype. Medicine (General) R5-920
spellingShingle	severe asthma children adolescents biological therapy endotype phenotype. Medicine (General) R5-920 Votto M De Filippo M Licari A Marseglia A De Amici M Marseglia GL Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review
description	Martina Votto,1,2,* Maria De Filippo,1,2,* Amelia Licari,1,2 Alessia Marseglia,2 Mara De Amici,3 Gian Luigi Marseglia1,2 1Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; 3Immuno-Allergology Laboratory, Clinical Chemistry Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy*These authors contributed equally to this workCorrespondence: Amelia LicariPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, p.le C. Golgi n.19, Pavia, 27100, ItalyTel/Fax +390382502629Email amelia.licari@unipv.itAbstract: Severe uncontrolled asthma is a complex and heterogeneous disease. A multidisciplinary assessment is required to correctly identify and manage children and adolescents with severe asthma because they may require strict monitoring and additional treatment with advanced targeted therapies. Recent research efforts have focused on identifying epidemiologic, clinical, and molecular mechanisms that underlie severe asthma, leading to the recognition of different phenotypes and endotypes and identifying biomarkers able to predict the response to biologic therapies. Additional progress has occurred by introducing biological therapies that have revolutionized the care of chronic allergic diseases in the adult and pediatric population. In this review, we briefly summarized the current literature on biological therapies to treat severe asthma in children and adolescents.Keywords: severe asthma, children, adolescents, biological therapy, endotype, phenotype
format	article
author	Votto M De Filippo M Licari A Marseglia A De Amici M Marseglia GL
author_facet	Votto M De Filippo M Licari A Marseglia A De Amici M Marseglia GL
author_sort	Votto M
title	Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review
title_short	Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review
title_full	Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review
title_fullStr	Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review
title_full_unstemmed	Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review
title_sort	biological therapies in children and adolescents with severe uncontrolled asthma: a practical review
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f937ff8b73ab4825868d273091a4c945
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Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review

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